mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
机构:
Univ Paris 07, EMI,U9922, INSERM, IFR 02,Hop Bichat Claude Bernard,AP HP, F-75877 Paris 18, FranceUniv Paris 07, EMI,U9922, INSERM, IFR 02,Hop Bichat Claude Bernard,AP HP, F-75877 Paris 18, France
机构:
Univ Paris 07, EMI,U9922, INSERM, IFR 02,Hop Bichat Claude Bernard,AP HP, F-75877 Paris 18, FranceUniv Paris 07, EMI,U9922, INSERM, IFR 02,Hop Bichat Claude Bernard,AP HP, F-75877 Paris 18, France