Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

被引：218

作者：

Hazan, R ^{[1
]}

Sat, B ^{[1
]}

Engelberg-Kulka, H ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biol Mol, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 11期

关键词：

D O I：

10.1128/JB.186.11.3663-3669.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

引用

页码：3663 / 3669

页数：7

共 46 条

[1] Regulation of the alternative sigma factor σΕ during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli
Ades, SE
Grigorova, IL
Gross, CA
[J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (08) : 2512 - 2519
[2] Thymine metabolism and thymineless death in prokaryotes and eukaryotes
Ahmad, SI
Kirk, SH
Eisenstark, A
[J]. ANNUAL REVIEW OF MICROBIOLOGY, 1998, 52 : 591 - 625
[3] An Escherichia coli chromosomal ''addiction module'' regulated by 3',5'-bispyrophosphate: A model for programmed bacterial cell death
Aizenman, E
EngelbergKulka, H
Glaser, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 6059 - 6063
[4] On the origin, evolution, and nature of programmed cell death: a timeline of four billion years
Ameisen, JC
[J]. CELL DEATH AND DIFFERENTIATION, 2002, 9 (04) : 367 - 393
[5] ISOLATION AND STRUCTURE OF AN INTRASTRAND CROSS-LINK ADDUCT OF MITOMYCIN-C AND DNA
BIZANEK, R
MCGUINNESS, BF
NAKANISHI, K
TOMASZ, M
[J]. BIOCHEMISTRY, 1992, 31 (12) : 3084 - 3091
[6] DNA damage-proces sing in E-coli:: on-going protein synthesis is required for fixation of UV-induced lethality and mutation
Burger, A
Raymer, J
Bockrath, R
[J]. DNA REPAIR, 2002, 1 (10) : 821 - 831
[7] Cashel M, 1996, ESCHERICHIA COLI SAL, P1458
[8] Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA
Christensen, SK
Pedersen, K
Hansen, FG
Gerdes, K
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2003, 332 (04) : 809 - 819
[9] ReIE, a global inhibitor of translation, is activated during nutritional stress
Christensen, SK
Mikkelsen, M
Pedersen, K
Gerdes, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) : 14328 - 14333
[10] Bacterial death by DNA gyrase poisoning
Couturier, M
Bahassi, E
Van Melderen, L
[J]. TRENDS IN MICROBIOLOGY, 1998, 6 (07) : 269 - 275

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