Multilevel surface engineering of nanostructured TiO2 on carbon-fiber-reinforced polyetheretherketone

被引：99

作者：

Lu, Tao ^{[1
]}

Liu, Xuanyong ^{[1
]}

Qian, Shi ^{[1
]}

Cao, Huiliang ^{[1
]}

Qiao, Yuqin ^{[1
]}

Mei, Yongfeng ^{[2
]}

Chu, Paul K. ^{[3
]}

Ding, Chuanxian ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Fudan Univ, Dept Mat Sci, Shanghai 200433, Peoples R China

[3] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China

来源：

BIOMATERIALS | 2014年 / 35卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Carbon-fiber-reinforced polyetheretherketone; Nanopores; Plasma immersion ion implantation; Osteogenic activity; Antibacterial activity; IMMERSION ION-IMPLANTATION; ETHER-ETHER-KETONE; TITANIUM SURFACES; CELL FATE; PLASMA; DIFFERENTIATION; BIOMATERIALS; DEPOSITION; COMPOSITES; NANOTUBES;

D O I：

10.1016/j.biomaterials.2014.04.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As an implantable material, carbon-fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to that of cortical bone and is a prime candidate to replace metallic surgical implants. However, the bioinertness and poor osteogenic properties of CFRPEEK limit its clinical application as orthopedic implants. In this work, titanium ions are introduced energetically into CFRPEEK by plasma immersion ion implantation (PIII). Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) reveal the formation of nanopores with the side wall and bottom embedded with similar to 20 nm TiO2 nanoparticles on the CFRPEEK surface. Nanoindentation measurements confirm the stability and improved elastic resistance of the structured surfaces. In vitro cell adhesion, viability assay, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteo-differentiation of rat bone mesenchymal stem cells (bMSCs). The multilevel structures on CFRPEEK also exhibit partial antibacterial activity to Staphylococcus aureus and Escherichia coli. Our results indicate that a surface with multifunctional biological properties can be produced by multilevel surface engineering and application of CFRPEEK to orthopedic and dental implants can be broadened and expedited based on this scheme. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5731 / 5740

页数：10

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