Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides

被引：59
作者：
Li, Minyan [1 ]
Berritt, Simon [1 ]
Walsh, Patrick J. [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Penn Merck Lab High Throughput Expt, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 16期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
ALLYL DIPHENYLGLYCINATE IMINES; OXIDATIVE ADDITION; DECARBOXYLATIVE ALLYLATION; LIGAND; COMPLEX; HALIDE; MECHANISM;
D O I：
10.1021/ol502043j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylation protocol was also developed.
引用
收藏
页码：4312 / 4315
页数：4
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