Simple, robust and accurate high-performance liquid chromatography method for the analysis of several anthelmintics in veterinary formulations

被引：25

作者：

vanTonder, EC ^{[1
]}

deVilliers, MM ^{[1
]}

Handford, JS ^{[1
]}

Malan, CEP ^{[1
]}

duPreez, JL ^{[1
]}

机构：

[1] POTCHEFSTROOM UNIV CHRISTIAN HIGHER EDUC,RES INST IND PHARM,POTCHEFSTROOM 2520,SOUTH AFRICA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 729卷 / 1-2期

关键词：

pharmaceutical analysis; anthelmintics; albendazole; fenbendazole; niclosamide; oxyclozanide;

D O I：

10.1016/0021-9673(95)01253-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, specific and accurate reversed-phase high-performance liquid chromatographic method to assay several anthelmintics in veterinary products is reported. The drugs analysed included albendazole, fenbendazole, niclosamide and oxyclozanide. This method afforded rapid and efficient separation, good resolution and identification of all the examined compounds, alone or combined. Method validation included range, linearity, precision, accuracy, specificity and recovery. The method was used to quantify these drugs, alone or in combination, in tablet, powder and liquid formulations.

引用

页码：267 / 272

页数：6