A Flexible Terahertz Metamaterial Biosensor for Cancer Cell Growth and Migration Detection

被引：22
作者：
Fang, Weihao [1 ,2 ]
Lv, Xiaoqing [1 ]
Ma, Zhengtai [1 ,2 ]
Liu, Jian [3 ]
Pei, Weihua [1 ]
Geng, Zhaoxin [4 ]
机构：
[1] Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelect, Beijing 100083, Peoples R China
[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Inst Semicond, Key Lab Superlattices & Microstruct, Beijing 100083, Peoples R China
[4] Minzu Univ China, Sch Informat Engn, Beijing 100081, Peoples R China
来源：
MICROMACHINES | 2022年 / 13卷 / 04期
关键词：
terahertz metamaterial; biosensor; cell migration; transform growth factor-beta; TRANSPARENCY-LIKE METAMATERIALS; SENSOR;
D O I：
10.3390/mi13040631
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Metamaterial biosensors have been extensively used to identify cell types and detect concentrations of tumor biomarkers. However, the methods for in situ and non-destruction measurement of cell migration, which plays a key role in tumor progression and metastasis, are highly desirable. Therefore, a flexible terahertz metamaterial biosensor based on parylene C substrate was proposed for label-free and non-destructive detection of breast cancer cell growth and migration. The maximum resonance peak frequency shift achieved 183.2 GHz when breast cancer cell MDA-MB-231 was cultured onto the surface of the metamaterial biosensor for 72 h. A designed polydimethylsiloxane (PDMS) barrier sheet was applied to detect the cell growth rate which was quantified as 14.9 mu m/h. The experimental peak shift expressed a linear relationship with the covered area and a quadratic relationship with the distance, which was consistent with simulation results. Additionally, the cell migration indicated that the transform growth factor-beta (TGF-beta) promoted the cancer cell migration. The terahertz metamaterial biosensor shows great potential for the investigation of cell biology in the future.
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页数：12
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