Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?

被引：6

作者：

Faria-Urbina, Mariana ^{[1
,2
,3
]}

Oliveira, Rudolf K. F. ^{[1
,2
,3
,4
]}

Segrera, Sergio A. ^{[1
,2
,3
]}

Lawler, Laurie ^{[1
,2
,3
]}

Waxman, Aaron B. ^{[1
,2
,3
]}

Systrom, David M. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA USA

[3] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

[4] Fed Univ Sao Paulo UNIFESP, Dept Med, Div Resp Dis, Sao Paulo, SP, Brazil

来源：

PULMONARY CIRCULATION | 2018年 / 8卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

systemic oxygen extraction; pulmonary hypertension; ambrisentan; exercise; ENDOTHELIAL DYSFUNCTION; DIAGNOSIS; TOLERANCE;

D O I：

10.1177/2045893218755325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that improved pulmonary hemodynamics at maximum exercise "unmasked" a pre-existing skeletal muscle abnormality.

引用

页数：4

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