Amyloidosis inhibition, a new frontier of the protein corona

被引:38
作者
Chen, Pengyu [1 ]
Ding, Feng [2 ]
Cai, Rong [3 ,4 ,9 ]
Javed, Ibrahim [5 ,6 ,7 ]
Yang, Wen [1 ]
Zhang, Zhenzhen [2 ]
Li, Yuhuan [5 ,8 ]
Davis, Thomas P. [5 ,6 ,7 ]
Ke, Pu Chun [5 ,8 ]
Chen, Chunying [3 ,4 ,9 ]
机构
[1] Auburn Univ, Mat Res & Educ Ctr, Auburn, AL 36849 USA
[2] Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA
[3] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[4] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[5] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, 381 Royal Parade, Parkville, Vic 3052, Australia
[6] Univ Queensland, ARC Ctr Excellence Convergent Bionano Sci & Techn, Brisbane, Qld 4072, Australia
[7] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia
[8] Fudan Univ, Zhongshan Hosp, 111 Yixueyuan Rd, Shanghai, Peoples R China
[9] Chinese Acad Med Sci, Res Unit Nanosci & Technol, Beijing 100039, Peoples R China
基金
澳大利亚研究理事会;
关键词
Amyloidosis; Nanoparticle inhibitor; Protein corona; Cytokine; Amyloid protein corona; BETA PEPTIDE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; CARBON NANOTUBES; NANOPARTICLES; FIBRILLATION; TOXICITY; AGGREGATION; GRAPHENE; FIBRILS;
D O I
10.1016/j.nantod.2020.100937
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The protein corona has served as a central dogma and a nuisance to the applications of nanomedicine and nanobiotechnology for well over a decade. Here we introduce the emerging field of amyloidosis inhibition, which aims to understand and harness the interfacial phenomena associated with a nanoparticle interacting with pathogenic amyloid proteins. Much of this interaction correlates with our understanding of the protein corona, and yet much differs, as elaborated for the first time in this Perspective. Specifically, we examine the in vitro, in silico and in vivo features of the new class of "amyloid protein corona", and discuss how the interactions with nanoparticles may halt the self-assembly of amyloid proteins. As amyloidosis is driven off pathway by the nanoparticles, the oligomeric and protofibrillar populations are suppressed to ameliorate their cytotoxicity. Furthermore, as amyloid proteins spread via the transport of bodily fluids or cross seeding, amyloidosis is inherently associated with dynamic proteins and ligands to evoke the immune system. Accordingly, we ponder the structural and medical implications of the amyloid protein corona in the presence of their stimulated cytokines. Understanding and exploiting the amyloid protein corona may facilitate the development of new theranostics against a range of debilitating amyloid diseases. (C) 2020 Elsevier Ltd. All rights reserved.
引用
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页数:13
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