Increased plasma levels of high mobility group box 1 protein in patients with bipolar disorder: A pilot study

被引：5
|
作者：
Marie-Claire, Cynthia [1 ]
Courtin, Cindie [1 ]
Curis, Emmanuel [1 ,2 ,3 ]
Bouaziz-Amar, Elodie [1 ,4 ]
Laplanche, Jean-Louis [1 ,4 ]
Jacob, Aude [1 ]
Etain, Bruno [1 ,5 ,6 ]
Blanchard, Anne [7 ]
Bellivier, Frank [1 ,5 ,6 ]
机构：
[1] Univ Paris Diderot, Univ Sorbonne Paris Cite, Univ Paris Descartes, INSERM Optimisat Therapeut Neuropsychopharmacol U, Paris, France
[2] GH St Louis Lariboisiere F Widal, AP HP, Dept Biostat & Informat Med, Paris, France
[3] Univ Paris 05, Fac Pharm Paris, Lab Biomath, Plateau iB2,EA 7537 BioSTM, F-75006 Paris, France
[4] GH St Louis Lariboisiere F Widal, Dept Biochim & Biol Mol, Paris, France
[5] GH St Louis Lariboisiere F Widal, AP HP, Pole Psychiat & Med Addictol, F-75475 Paris 10, France
[6] Fondat Fondamental, Creteil, France
[7] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, INSERM CIC1418, F-75015 Paris, France
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 334卷
关键词：
HMGB1; Bipolar disorder; Plasma; Inflammation; C-REACTIVE PROTEIN; HMGB1; CELLS; ASSOCIATION; CYTOKINES; ABUNDANCE; BIOMARKER; STRESS;
D O I：
10.1016/j.jneuroim.2019.576993
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as compared to control subjects whereas C-reactive protein levels did not differ between the two groups. No significant effect of potential covariates was identified. The results of this pilot study suggest that HMGB1 might be a specific peripheral marker of inflammation in BD.
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页数：4
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