Calcium-dependent interaction of transducin with calmodulin-sepharose

被引:0
作者
Grishchenko, V. M. [1 ]
Orlova, T. G. [1 ]
Freidin, A. A. [1 ]
Orlov, N. Y. [1 ]
机构
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia
来源
BIOFIZIKA | 2006年 / 51卷 / 05期
关键词
G proteins; transducin; calmodulin; phototransductian systems;
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
It has been shown by affinity chromatography on calmodulin-sepharose that transducin, a G protein of bovine retinal rod outer segments interacts with Ca2+-calmodulin. This result assumes that the main part of calmodulin in dark retinal rod outer segments is associated with transducin. It has been suggested that photoactivation of retinal rods induces changes in intracellular calmodulin concentration, which may be one of the steps involved in the light adaptation of photoreceptor.
引用
收藏
页码:817 / 821
页数:5
相关论文
共 39 条
[1]   INTERACTION OF GTP-BINDING PROTEINS WITH CALMODULIN [J].
ASANO, T ;
OGASAWARA, N ;
KITAJIMA, S ;
SANO, M .
FEBS LETTERS, 1986, 203 (02) :135-138
[2]   Cyclic GMP-gated channels of bovine rod photoreceptors: Affinity, density and stoichiometry of Ca2+-calmodulin binding sites [J].
Bauer, PJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1996, 494 (03) :675-685
[3]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4]   Activation, deactivation, and adaptation in vertebrate, photoreceptor cells [J].
Burns, ME ;
Baylor, DA .
ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :779-805
[5]   Insights into G protein structure, function, and regulation [J].
Cabrera-Vera, TM ;
Vanhauwe, J ;
Thomas, TO ;
Medkova, M ;
Preininger, A ;
Mazzoni, MR ;
Hamm, HE .
ENDOCRINE REVIEWS, 2003, 24 (06) :765-781
[6]   RECOVERIN - A CALCIUM SENSITIVE ACTIVATOR OF RETINAL ROD GUANYLATE-CYCLASE [J].
DIZHOOR, AM ;
RAY, S ;
KUMAR, S ;
NIEMI, G ;
SPENCER, M ;
BROLLEY, D ;
WALSH, KA ;
PHILIPOV, PP ;
HURLEY, JB ;
STRYER, L .
SCIENCE, 1991, 251 (4996) :915-918
[7]   Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins [J].
Dizhoor, AM ;
Hurley, JB .
METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, 1999, 19 (04) :521-531
[8]   The G protein subunit gene families [J].
Downes, GB ;
Gautam, N .
GENOMICS, 1999, 62 (03) :544-552
[9]   Vertebrate photoreceptors [J].
Ebrey, T ;
Koutalos, Y .
PROGRESS IN RETINAL AND EYE RESEARCH, 2001, 20 (01) :49-94
[10]   Adaptation in vertebrate photoreceptors [J].
Fain, GL ;
Matthews, HR ;
Cornwall, MC ;
Koutalos, Y .
PHYSIOLOGICAL REVIEWS, 2001, 81 (01) :117-151