What is on the horizon for improved treatments for acutely decompensated heart failure?

被引：0

作者：

Diez, Javier ^{[1
,2
]}

Bayes-Genis, Antoni ^{[3
,4
,5
]}

机构：

[1] Univ Navarra, Univ Navarra Clin, Program Cardiovasc Dis, Dept Cardiol & Cardiac Surg, Av Pio 12 55, Pamplona 31008, Spain

[2] Univ Navarra, Univ Navarra Clin, Ctr Appl Med Res, Av Pio 12 55, Pamplona 31008, Spain

[3] Univ Germans Trias & Pujol, Cardiol Serv, Ctra Canyet S-N 08, Badalona 08916, Spain

[4] Univ Germans Trias & Pujol, Heart Failure Unit, Ctra Canyet S-N 08, Badalona 08916, Spain

[5] Autonomous Univ Barcelona, Dept Med, E-08193 Barcelona, Spain

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2016年 / 18卷 / 0G期

关键词：

Acute heart failure; Unmet need; Novel therapies; Biomarkers; Organ damage; Clinical management; ARRESTIN-BIASED LIGAND; ANGIOTENSIN-2; TYPE-1; RECEPTOR; CHIMERIC NATRIURETIC PEPTIDE; GUANYLATE-CYCLASE STIMULATOR; CARDIAC-MYOSIN-ACTIVATORS; CALCIUM UP-REGULATION; RELAX-AHF; CD-NP; EJECTION FRACTION; BLOOD-PRESSURE;

D O I：

10.1093/eurheartj/suw043

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients hospitalized with acutely decompensated heart failure (ADHF) are often critically ill and require immediate treatment to stabilize their haemodynamic status. Despite improving the signs and symptoms of ADHF, currently available therapies have failed to demonstrate improvements in post-discharge outcomes, such as mortality and rehospitalization, and to address the impact of end-organ damage. Furthermore, attempts to develop therapies to treat patients with ADHF over the past 10 to 20 years have been largely unsuccessful, further compounding the problem. Recent evidence supporting a variety of novel therapies, such as serelaxin and natriuretic peptides, may signal a new hope on the horizon for patients with ADHF.

引用

页码：G33 / G42

页数：10

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