Management of ruptured liver segment IV hepatocellular carcinoma: is transarterial embolization (TAE) superior to chemoembolization (TACE)?-the jury is still out

被引:4
作者
Bakopoulos, Anargyros [1 ]
Koliakos, Nikolaos [1 ]
Tsilimigras, Diamantis, I [1 ]
Schizas, Dimitrios [1 ]
Moris, Demetrios [2 ]
Angelopoulos, Argiris [3 ]
Spanakos, Spyridon [3 ]
Spartalis, Eleftherios [4 ]
Patapis, Pavlos [1 ]
Skandalakis, Panagiotis [3 ]
Troupis, Theodoros [3 ]
机构
[1] Univ Athens, Attikon Univ Hosp, Sch Med, Dept Surg 3, Rimini 1str, Athens 12462, Greece
[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
[3] Univ Athens, Fac Med, Dept Anat, Athens, Greece
[4] Univ Athens, Sch Med, Lab Expt Surg & Surg Res, Athens, Greece
关键词
Transarterial embolization (TAE); rupture; hepatocellular carcinoma (HCC); OUTCOMES;
D O I
10.21037/atm.2018.06.01
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
HCC rupture is a potentially life-threatening complication owing to underlying vascular dysfunction and coagulopathy. There is still a debate in the literature concerning the best approach in patients presenting in the emergency setting with shock due to spontaneous HCC rupture. In the current report, we describe the case of a 66-year-old female patient with ruptured HCC who was treated successfully by emergency transarterial embolization (TAP) with complete response proved by gradual shrinkage of the tumor. This impressive complete response suggests that TAE followed by elective hepatectomy could be an efficient approach for patients with Child-Pugh class A liver function and adequate liver remnant. More studies are needed in order to construct specific guidelines for the treatment of rHCC that will be based on the disease severity and the patient status.
引用
收藏
页数:5
相关论文
共 13 条
[1]  
American Joint Committee on Cancer, 2009, CANC STAGING MANUAL
[2]   NCCN Guidelines® Insights Hepatobiliary Cancers, Version 1.2017 Featured Updates to the NCCN Guidelines [J].
Benson, Al B., III ;
D'Angelica, Michael I. ;
Abbott, Daniel E. ;
Abrams, Thomas A. ;
Alberts, Steven R. ;
Saenz, Daniel Anaya ;
Are, Chandrakanth ;
Brown, Daniel B. ;
Chang, Daniel T. ;
Covey, Anne M. ;
Hawkins, William ;
Iyer, Renuka ;
Jacob, Rojymon ;
Karachristos, Andrea ;
Kelley, R. Kate ;
Kim, Robin ;
Palta, Manisha ;
Park, James O. ;
Sahai, Vaibhav ;
Schefter, Tracey ;
Schmidt, Carl ;
Sicklick, Jason K. ;
Singh, Gagandeep ;
Sohal, Davendra ;
Stein, Stacey ;
Tian, G. Gary ;
Vauthey, Jean-Nicolas ;
Venook, Alan P. ;
Zhu, Andrew X. ;
Hoffmann, Karin G. ;
Darlow, Susan .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (05) :563-573
[3]   Bland Embolization in Patients with Unresectable Hepatocellular Carcinoma Using Precise, Tightly Size-Calibrated, Anti-Inflammatory Microparticles: First Clinical Experience and One-Year Follow-Up [J].
Bonomo, Guido ;
Pedicini, Vittorio ;
Monfardini, Lorenzo ;
Della Vigna, Paolo ;
Poretti, Dario ;
Orgera, Gianluigi ;
Orsi, Franco .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2010, 33 (03) :552-559
[4]   Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone [J].
Brown, Karen T. ;
Do, Richard K. ;
Gonen, Mithat ;
Covey, Anne M. ;
Getrajdman, George I. ;
Sofocleous, Constantinos T. ;
Jarnagin, William R. ;
D'Angelica, Michael I. ;
Allen, Peter J. ;
Erinjeri, Joseph P. ;
Brody, Lynn A. ;
O'Neill, Gerald P. ;
Johnson, Kristian N. ;
Garcia, Alessandra R. ;
Beattie, Christopher ;
Zhao, Binsheng ;
Solomon, Stephen B. ;
Schwartz, Lawrence H. ;
DeMatteo, Ronald ;
Abou-Alfa, Ghassan K. .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (17) :2046-+
[5]  
Choo SP, 2016, CANCER
[6]   Surveillance, Diagnosis, Treatment, and Outcome of Liver Cancer in Japan [J].
Kudo, Masatoshi .
LIVER CANCER, 2015, 4 (01) :39-50
[7]   Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma [J].
Lencioni, Riccardo ;
Llovet, Josep M. .
SEMINARS IN LIVER DISEASE, 2010, 30 (01) :52-60
[8]   Transarterial therapy for hepatocellular carcinoma: Which technique is more effective? A systematic review of cohort and randomized studies [J].
Marelli, Laura ;
Stigliano, Rosa ;
Triantos, Christos ;
Senzolo, Marco ;
Cholongitas, Evangelos ;
Davies, Neil ;
Tibballs, Jonathan ;
Meyer, Tim ;
Patch, David W. ;
Burroughs, Andrew K. .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2007, 30 (01) :6-25
[9]   Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma [J].
Miraglia, Roberto ;
Pietrosi, Giada ;
Maruzzelli, Luigi ;
Petridis, Ioannis ;
Caruso, Settimo ;
Marrone, Gianluca ;
Mamone, Giuseppe ;
Vizzini, Giovanni ;
Luca, Angelo ;
Gridelli, Bruno .
WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (21) :2952-2955
[10]   Management, outcomes, and prognostic factors of ruptured hepatocellular carcinoma: A systematic review [J].
Moris, Demetrios ;
Chakedis, Jeffery ;
Sun, Steven H. ;
Spolverato, Gaya ;
Tsilimigras, Diamantis I. ;
Ntanasis-Stathopoulos, Ioannis ;
Spartalis, Eleftherios ;
Pawlik, Timothy M. .
JOURNAL OF SURGICAL ONCOLOGY, 2018, 117 (03) :341-353