Novel synthesis of a tetra-substituted imidazole P38 MAP Kinase inhibitor and development of routes to a 2,4-disubstituted pyridine.

被引:0
|
作者
Marcantonio, KM [1 ]
Frey, LF [1 ]
Frantz, D [1 ]
Murry, J [1 ]
Soheili, A [1 ]
Tillyer, R [1 ]
Grabowski, EJJ [1 ]
Reider, P [1 ]
机构
[1] Merck & Co Inc, Merck Res Labs, Proc Res, Rahway, NJ 07065 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 224卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
740-ORGN
引用
收藏
页码:U234 / U234
页数:1
相关论文
共 30 条
  • [21] Selective regulation of T cell IL-5 synthesis by OM-01,JTE-711 and p38 map kinase inhibitor: Independent control of Th2 cytokines, IL-4 and IL-5
    Mori, A
    Okudaira, H
    Kobayashi, N
    Akiyama, K
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2001, 124 (1-3) : 172 - 175
  • [22] SB239063, a p38 MAP kinase inhibitor, inhibits development of psoriatic lesions as effectively as Cyclosporin A in C.B-17 SCID mice adoptively transferred with naive T cells from B10.D2 splenocytes
    McAdams, H
    Truneh, A
    Kou, J
    Eichman, C
    Davenport, C
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (02) : 463 - 463
  • [23] Identification of (1E, 3E)-1, 3-bis [(2-hydroxy-1-naphthyl) methylene] Urea as Mutated MAP Kinase P38 Inhibitor through Reverse Pharmacophore Mapping Approach: Green Synthesis, Characterisation and in silico Docking analysis
    Rajamma, Devika Bhai
    Iyerz, Girija Chamarahalli Ramakrishna
    Madar, Inamul Hasan
    Karunakar, Prashantha
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2019, 53 (02) : 276 - 285
  • [24] Targeting the r-spine: Design, synthesis, and biological evaluation of novel type I1/2 p38α MAP kinase inhibitors with excellent selectivity, high potency, and prolonged target residence time. Implication for cancer- and CNS-applications
    Laufer, Stefan
    Wentsch, Heike
    Walter, Niklas
    Laemmerhofer, Michael
    Buijsman, Roger
    Rauh, Daniel
    Zender, Lars
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [25] Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells:: A novel strategy to treat renal fibrosis
    Prakash, Jai
    Sandovici, Maria
    Saluja, Vinay
    Lacombe, Marie
    Schaapveld, Roel Q. J.
    de Borst, Martin H.
    van Goor, Harry
    Henning, Robert H.
    Proost, Johannes H.
    Moolenaar, Frits
    Keri, Gyorgy
    Meijer, Dirk K. F.
    Poelstra, Klaas
    Kok, Robbert J.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 319 (01): : 8 - 19
  • [26] Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP ldnase with reduced side effects based on the antedrug concept
    Hasumi, Koichi
    Sato, Shuichiro
    Saito, Takahisa
    Kato, Jun-ya
    Shirota, Kazuhiko
    Sato, Jun
    Suzuki, Hiroyuki
    Ohta, Shuji
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (15) : 4162 - 4176
  • [27] Novel inhibitor of p38 map kinase as an anti-TNF-&alpha drug:: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatic agent.
    Miwatashi, S
    Arikawa, Y
    Kotani, E
    Miyamoto, M
    Naruo, K
    Kimura, H
    Tanaka, T
    Asahi, S
    Ohkawa, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U130 - U130
  • [28] Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug:: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent
    Miwatashi, S
    Arikawa, Y
    Kotani, E
    Miyamoto, M
    Naruo, K
    Kimura, H
    Tanaka, T
    Asahi, S
    Ohkawa, S
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (19) : 5966 - 5979
  • [29] Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6, 7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor
    Asano, Toni
    Yamazaki, Hitoshi
    Kasahara, Chiyoshi
    Kubota, Hirokazu
    Kontani, Toni
    Harayama, Yu
    Ohno, Kazuki
    Mizuhara, Hidekazu
    Yokomoto, Masaharu
    Misumi, Keiji
    Kinoshita, Tomohiko
    Ohta, Mitsuaki
    Takeuchi, Makoto
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (17) : 7772 - 7785
  • [30] Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor (vol 55, pg 7772, 2012)
    Asano, Toru
    Yamazaki, Hitoshi
    Kasahara, Chiyoshi
    Kubota, Hirokazu
    Kontani, Toru
    Harayama, Yu
    Ohno, Kazuki
    Mizuhara, Hidekazu
    Yokomoto, Masaharu
    Misumi, Keiji
    Kinoshita, Tomohiko
    Ohta, Mitsuaki
    Takeuchi, Makoto
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (16) : 7143 - 7143