Fabrication of SnO2/porous silica/polyethyleneimine nanoparticles for pH-responsive drug delivery

被引：26

作者：

Cao, Na ^{[1
]}

Li, Miao ^{[2
]}

Zhao, Yanbao ^{[1
]}

Qiu, Li ^{[1
]}

Zou, Xueyan ^{[1
]}

Zhang, Yu ^{[2
]}

Sun, Lei ^{[1
]}

机构：

[1] Henan Univ, Engn Res Ctr Nanomat, Kaifeng 475004, Peoples R China

[2] Henan Univ, Key Lab Plant Stress Biol, Kaifeng 475004, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 59卷

基金：

中国国家自然科学基金;

关键词：

SnO2/porous silica/polyethyleneimine; Nanocarriers; PH-responsive; Drug delivery; Drug-dependent fluorescence; MESOPOROUS SILICA NANOPARTICLES; SNO2; NANOPARTICLES; NANOSPHERES; NANOGELS; RELEASE; CARRIER; DOTS;

D O I：

10.1016/j.msec.2015.10.032

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

To create novel nanocarriers for achieving excellent drug delivery performance, pH-responsive fluorescent porous silica (PS) nanocarriers were developed by encapsulating SnO2 nanoparticles and coating polyethyleneimine (PEI) layer. SnO2/porous silica (SnO2/PS) nanoparticles have an average diameter of 80 nm and center-radial large pore channels. The large channels endow them high surface area with a Brunauer-Emmett-Teller (BET) area of 939 m(2) g(-1). Aspirin was used as test drug to evaluate the releasing behavior of SnO2/porous silica/polyethyleneimine (SnO2/PS/PEI) nanoparticles. Results indicated that aspirin can be successfully incorporated into the SnO2/PS/PEI nanoparticles and the SnO2/PS/PEI nanoparticles displayed excellent pH-responsive release. The release rate in pH 7.4 buffer is higher than that in pH 5.5 buffer, which attributed to the PEI structure change in varied pH buffer. In addition, the SnO2/PS/PEI nanoparticles presented novel drug-dependent fluorescence, which could be used to trace the drug release. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：319 / 323

页数：5

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