Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

被引：52

作者：

Arung, Enos Tangke ^{[1
]}

Shimizu, Kuniyoshi ^{[1
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan

来源：

PLANTA MEDICA | 2006年 / 72卷 / 09期

关键词：

D O I：

10.1055/s-2006-931606

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

引用

页码：847 / 850

页数：4

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