An Alternative Treatment for Cervical Intraepithelial Neoplasia II, III

被引:3
作者
Swanick, Summer [1 ]
Windstar-Hamlin, Kimberly [1 ]
Zwickey, Heather [1 ]
机构
[1] Natl Coll Nat Med, Nat Hlth Ctr, Portland, OR 97210 USA
关键词
cervical dysplasia; complementary and alternative medicine; herbs; botanical medicine; escharotic; LEEP alternative; HUMAN-PAPILLOMAVIRUS INFECTION; ESCHAROTIC AGENTS; CANCER-CELLS; SKIN-CANCER; RISK; INDOLE-3-CARBINOL; SANGUINARINE; MANAGEMENT; PREGNANCY; FOLATE;
D O I
10.1177/1534735409335504
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. This report describes a case of a woman with progressive and recurrent cervical dysplasia 4 years after cervical Ionization for severe dysplasia. Patient and methods. A 20-year-old female was referred for colposcopy and biopsy following results of moderate to severe atypia of cervical cells on her Papanicolaou (Pap) test. Her colposcopy was satisfactory and her biopsy revealed cervical intraepithelial neoplasia (CIN) II, III. She refused the conventional recommendation of loop electrosurgical excision procedure (LEEP) and, as an alternative, elected to receive escharotic treatment at: a frequency of 2 treatments per week for 5 weeks. In addition to the escharotic treatment she followed an oral vitamin and botanical protocol. She was followed for 5 years. Results. The patient's 4-month and 10-month follow-up Pap smears revealed negative cervical cytology for intraepithelial lesion or malignancy. Her 10-month colposcopy was satisfactory and no lesions were noted on the colposcopic exam. Liquid based Pap results continued to remain normal for 5 years after the initiation of treatment. Discussion. Escharotic treatment of high-grade cervical neoplasias with satisfactory colposcopy holds promise as an effective and low-risk alternative therapy to LEEP and other excisional procedures.
引用
收藏
页码:164 / 167
页数:4
相关论文
共 28 条
[1]  
Ahmad N, 2000, CLIN CANCER RES, V6, P1524
[2]   Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions [J].
Ahn, WS ;
Yoo, J ;
Huh, SW ;
Kim, CK ;
Lee, JM ;
Namkoong, SE ;
Bae, SM ;
Lee, IP .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2003, 12 (05) :383-390
[3]   Can indole-3-carbinol-induced changes in cervical intraepithelial neoplasia be extrapolated to other food components? [J].
Auborn, Karen J. .
JOURNAL OF NUTRITION, 2006, 136 (10) :2676S-2678S
[4]   Placebo-controlled trial of indole-3-carbinol in the treatment of CIN [J].
Bell, MC ;
Crowley-Nowick, P ;
Bradlow, HL ;
Sepkovic, DW ;
Schmidt-Grimminger, D ;
Howell, P ;
Mayeaux, EJ ;
Tucker, A ;
Turbat-Herrera, EA ;
Mathis, JM .
GYNECOLOGIC ONCOLOGY, 2000, 78 (02) :123-129
[5]   Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium [J].
Chen, DZ ;
Qi, M ;
Auborn, KJ ;
Carter, TH .
JOURNAL OF NUTRITION, 2001, 131 (12) :3294-3302
[6]   Management of cervical intraepithelial neoplasia [J].
Cox, JT .
LANCET, 1999, 353 (9156) :857-859
[7]   Transvaginal ultrasonography in the prediction of preterm birth after treatment for cervical intraepithelial neoplasia [J].
Crane, JMG ;
Delaney, T ;
Hutchens, D .
OBSTETRICS AND GYNECOLOGY, 2006, 107 (01) :37-44
[8]  
DELLALOGGIA R, 1994, PLANTA MED, V60, P516, DOI 10.1055/s-2006-959562
[9]   Escharotic agents, Fred Mohs, and Harry Hoxsey [J].
Elston, DM .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2005, 53 (03) :523-525
[10]   Suppression of angiogenesis by the plant alkaloid, sanguinarine [J].
Eun, JP ;
Koh, GY .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (02) :618-624