Targeting Mitophagy in Alzheimer's Disease

被引：12

作者：

Jayatunga, Dona P. W. ^{[1
]}

Hone, Eugene ^{[1
,2
]}

Bharadwaj, Prashant ^{[1
,2
]}

Garg, Manohar ^{[3
,4
]}

Verdile, Giuseppe ^{[1
,5
]}

Guillemin, Gilles J. ^{[6
,7
]}

Martins, Ralph N. ^{[1
,8
,9
,10
,11
]}

机构：

[1] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Med & Hlth Sci, Joondalup, WA, Australia

[2] Cooperat Res Ctr Mental Hlth, Carlton, Vic, Australia

[3] Univ Newcastle, Fac Hlth & Med, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia

[4] Massey Univ, Riddet Inst, Palmerston North, New Zealand

[5] Curtin Univ, Fac Hlth Sci, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

[6] Univ New South Wales, Fac Med, Sch Med Sci, Dept Pharmacol, Sydney, NSW, Australia

[7] St Vincents Ctr Appl Med Res, Sydney, NSW, Australia

[8] Australian Alzheimers Res Fdn, Ralph & Patricia Sarich Neurosci Res Inst, Nedlands, WA, Australia

[9] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[10] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA, Australia

[11] KaRa Inst Neurol Dis, Sydney, NSW, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 78卷 / 04期

关键词：

Alzheimer's disease; mitophagy; neuroprotection; nutraceuticals; MICROTUBULE-ASSOCIATED PROTEIN; MITOCHONDRIAL QUALITY-CONTROL; MILD COGNITIVE IMPAIRMENT; ELECTRON-TRANSPORT CHAIN; REACTIVE OXYGEN; CALORIC RESTRICTION; AMYLOID-BETA; OXIDATIVE STRESS; SKELETAL-MUSCLE; LIFE-SPAN;

D O I：

10.3233/JAD-191258

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mitochondria perform many essential cellular functions including energy production, calcium homeostasis, transduction of metabolic and stress signals, and mediating cell survival and death. Maintaining viable populations of mitochondria is therefore critical for normal cell function. The selective disposal of damaged mitochondria, by a pathway known as mitophagy, plays a key role in preserving mitochondrial integrity and quality. Mitophagy reduces the formation of reactive oxygen species and is considered as a protective cellular process. Mitochondrial dysfunction and deficits of mitophagy have important roles in aging and especially in neurodegenerative disorders such as Alzheimer's disease (AD). Targeting mitophagy pathways has been suggested to have potential therapeutic effects against AD. In this review, we aim to briefly discuss the emerging concepts on mitophagy, molecular regulation of the mitophagy process, current mitophagy detection methods, and mitophagy dysfunction in AD. Finally, we will also briefly examine the stimulation of mitophagy as an approach for attenuating neurodegeneration in AD.

引用

页码：1273 / 1297

页数：25

共 314 条

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