Effect of Exercise on Markers of Vascular Health in Renal Transplant Recipients

被引:8
作者
Pitha, J. [1 ]
Lesna, I. Kralova [1 ]
Stavek, P. [1 ]
Mahrova, A. [2 ]
Racek, J. [3 ]
Sekerkova, A. [4 ]
Teplan, V. [5 ]
Stollova, M. [5 ]
机构
[1] Inst Clin & Expt Med, Ctr Med Expt, Prague 14021 4, Czech Republic
[2] Charles Univ Prague, Fac Phys Educ & Sport, Prague, Czech Republic
[3] Charles Univ Prague, Inst Clin Biochem & Hematol, Fac Med, Plzen, Czech Republic
[4] Inst Clin & Expt Med, Dept Clin & Transplant Immunol, Prague 14021 4, Czech Republic
[5] Inst Clin & Expt Med, Transplant Ctr, Dept Nephrol, Prague 14021 4, Czech Republic
关键词
Renal transplantation; Exercise; Endothelial progenitor cells; Circulating microparticles; Asymmetric dimethyl arginine; ENDOTHELIAL PROGENITOR CELLS; ASYMMETRIC DIMETHYLARGININE;
D O I
10.33549/physiolres.933123
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The cornerstone of cardiovascular risk management is lifestyle intervention including exercise which could exert favorable impact also in renal transplant recipients. Nevertheless, reliable assessment of the effect of lifestyle interventions is complicated and the available data in this population are not consistent. The aim of the study was to evaluate the effect of physical activity on selected laboratory markers of vascular health including circulating stem cells, endothelial progenitor cells, microparticles, and plasma asymmetric dimethyl arginine in renal transplant recipients. Nineteen men and 7 women were recruited in 6-month program of standardized and supervised exercise. Control group consisted of 23 men and 13 women of similar age and body mass index not included into the program. One year after the transplantation, the main difference between intervention and control group was found in the change of endothelial progenitor cells (p=0.006). Surprisingly, more favorable change was seen in the control group in which endothelial progenitor cells significantly increased compared to the intervention group. The explanation of this finding might be a chronic activation of reparative mechanisms of vascular system in the population exposed to multiple risk factors which is expressed as relatively increased number of endothelial progenitor cells. Therefore, their decrease induced by exercise might reflect stabilization of these processes.
引用
收藏
页码:945 / 949
页数:5
相关论文
共 12 条
[1]   Association of asymmetric dimethylarginine and endothelial dysfunction [J].
Böger, RH .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2003, 41 (11) :1467-1472
[2]   Endothelial progenitor cells in chronic renal insufficiency [J].
Herbrig, Kay ;
Pistrosch, Frank ;
Foerster, Sarah ;
Gross, Peter .
KIDNEY & BLOOD PRESSURE RESEARCH, 2006, 29 (01) :24-31
[3]   Endothelial Dysfunction Expressed as Endothelial Microparticles in Patients With End-Stage Heart Failure [J].
Ivak, P. ;
Pitha, J. ;
Wohlfahrt, P. ;
Lesna, I. Kralova ;
Stavek, P. ;
Dorazilova, Z. ;
Stepankova, J. ;
Maly, J. ;
Pokorny, M. ;
Netuka, I. .
PHYSIOLOGICAL RESEARCH, 2014, 63 :S369-S373
[4]   Regular physical exercise normalizes elevated asymmetrical dimethylarginine concentrations in patients with type 1 diabetes mellitus [J].
Mittermayer, F ;
Pleiner, J ;
Krzyzanowska, K ;
Wiesinger, GF ;
Francesconi, M ;
Wolzt, M .
WIENER KLINISCHE WOCHENSCHRIFT, 2005, 117 (23-24) :816-820
[5]   Gender-Related Determinants of Advanced Subclinical Atherosclerosis in Patients Undergoing Kidney Transplantation [J].
Pitha, Jan ;
Teplan, Vladimir ;
Kalousova, Marta ;
Racek, Jaroslav ;
Stollova, Milena ;
Mareckova, Olga ;
Lanska, Vera .
KIDNEY & BLOOD PRESSURE RESEARCH, 2010, 33 (03) :227-234
[6]   Effect of Conversion From Ciclosporin to Tacrolimus on Endothelial Progenitor Cells in Stable Long-Term Kidney Transplant Recipients [J].
Riegersperger, Markus ;
Plischke, Max ;
Steiner, Sabine ;
Seidinger, Daniela ;
Sengoelge, Guerkan ;
Winkelmayer, Wolfgang C. ;
Sunder-Plassmann, Gere .
TRANSPLANTATION, 2013, 95 (11) :1338-1345
[7]   Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects [J].
Rocha, Natalia G. ;
Sales, Allan R. K. ;
Miranda, Renan L. ;
Silva, Mayra S. ;
Silva, Jemima F. R. ;
Silva, Bruno M. ;
Santos, Aline A. ;
Nobrega, Antonio C. L. .
LIFE SCIENCES, 2015, 123 :93-99
[8]   Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: A randomized controlled trial [J].
Schlager, Oliver ;
Giurgea, Aura ;
Schuhfried, Othmar ;
Seidinger, Daniela ;
Hammer, Alexandra ;
Groeger, Marion ;
Fialka-Moser, Veronika ;
Gschwandtner, Michael ;
Koppensteiner, Renate ;
Steiner, Sabine .
ATHEROSCLEROSIS, 2011, 217 (01) :240-248
[9]  
Slavik L, 2010, IN VITRO DIAGNOSTIC, V16, P19
[10]   Endothelial progenitor cells in kidney transplant recipients [J].
Steiner, S ;
Winkelmayer, WC ;
Kleinert, J ;
Grisar, J ;
Seldinger, D ;
Kopp, CW ;
Watschinger, B ;
Minar, E ;
Hörl, WH ;
Födinger, M ;
Sunder-Plassniann, G .
TRANSPLANTATION, 2006, 81 (04) :599-606