Purinergic signalling in the kidney in health and disease

被引：45

作者：

Burnstock, Geoffrey ^{[1
,2
]}

Evans, Louise C. ^{[3
]}

Bailey, Matthew A. ^{[3
]}

机构：

[1] UCL, Auton Neurosci Ctr, Sch Med, London NW3 2PF, England

[2] Univ Melbourne, Dept Pharmacol, Parkville, Vic 3010, Australia

[3] Univ Edinburgh, Univ British Heart Fdn Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

来源：

PURINERGIC SIGNALLING | 2014年 / 10卷 / 01期

关键词：

Glomerulus; Tubules; Sodium transport; ATP release; Kidney failure; Diabetes; PROXIMAL TUBULE CELLS; RAT MESANGIAL CELLS; ADENOSINE A(1) RECEPTOR; THICK ASCENDING LIMB; EXTRACELLULAR ATP INCREASES; EPITHELIAL SODIUM-CHANNEL; ACUTE-RENAL-FAILURE; TUBULOGLOMERULAR FEEDBACK-REGULATION; AVP-INDEPENDENT REGULATION; SENSITIVE P2X(7) RECEPTOR;

D O I：

10.1007/s11302-013-9400-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

引用

页码：71 / 101

页数：31

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