Recommended vaccinations for asplenic and hyposplenic adult patients

被引：72

作者：

Bonanni, Paolo ^{[1
]}

Grazzini, Maddalena ^{[2
]}

Niccolai, Giuditta ^{[2
]}

Paolini, Diana ^{[2
]}

Varone, Ornella ^{[2
]}

Bartoloni, Alessandro ^{[3
,4
]}

Bartalesi, Filippo ^{[3
,4
]}

Santini, Maria Grazia ^{[5
]}

Baretti, Simonetta ^{[5
]}

Bonito, Carlo ^{[5
]}

Zini, Paola ^{[5
]}

Mechi, Maria Teresa ^{[6
]}

Niccolini, Fabrizio ^{[7
]}

Magistri, Lea ^{[7
]}

Pulci, Maria Beatrice ^{[7
]}

Boccalini, Sara ^{[1
]}

Bechinia, Angela ^{[1
]}

机构：

[1] Univ Florence, Dept Hlth Sci, I-50134 Florence, Italy

[2] Univ Florence, Specializat Med Sch, Hygiene & Prevent Med, I-50121 Florence, Italy

[3] Univ Florence, Dept Expt & Clin Med, I-50121 Florence, Italy

[4] Careggi Univ Hosp, Infectious & Trop Dis Unit, Florence, Italy

[5] Reg Hlth Serv, Local Hlth Unit Florence, Operat Unit Hygiene & Publ Hlth, Florence, Italy

[6] Tuscany Reg, Rights Citizenship & Soc Cohes, Florence, Italy

[7] Careggi Univ Hosp, Hlth Direct, Florence, Italy

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2017年 / 13卷 / 02期

关键词：

asplenic; hyposplenic; infectious diseases; prevention; recommendations; splenectomy; vaccinations; INFLUENZAE TYPE-B; PNEUMOCOCCAL CONJUGATE VACCINE; ACELLULAR PERTUSSIS-VACCINE; YOUNG-ADULTS; POLYSACCHARIDE VACCINES; IMMUNE-RESPONSE; SEROGROUP-C; CHILDREN; IMMUNOGENICITY; INFECTIONS;

D O I：

10.1080/21645515.2017.1264797

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Asplenic or hyposplenic (AH) individuals are particularly vulnerable to invasive infections caused by encapsulated bacteria. Such infections have often a sudden onset and a fulminant course. Infectious diseases (IDs) incidence in AH subjects can be reduced by preventive measures such as vaccination. The aim of our work is to provide updated recommendations on prevention of infectious diseases in AH adult patients, and to supply a useful and practical tool to healthcare workers for the management of these subjects, in hospital setting and in outpatients consultation. A systematic literature review on evidence based measures for the prevention of IDs in adult AH patients was performed in 2015. Updated recommendations on available vaccines were consequently provided. Vaccinations against S. pneumoniae, N. meningitidis, H. influenzae type b and influenza virus are strongly recommended and should be administered at least 2 weeks before surgery in elective cases or at least 2 weeks after the surgical intervention in emergency cases. In subjects without evidence of immunity, 2 doses of live attenuated vaccines against measles-mumps-rubella and varicella should be administered 4-8 weeks apart from each other; a booster dose of tetanus, diphtheria and pertussis vaccine should be administered also to subjects fully vaccinated, and a 3-dose primary vaccination series is recommended in AH subjects with unknown or incomplete vaccination series (as in healthy people). Evidence based prevention data support the above recommendations to reduce the risk of infection in AH individuals.

引用

页码：359 / 368

页数：10

共 78 条

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