Renal Artery Stenosis and Renal Parenchymal Damage in Patients with Abdominal Aortic Aneurysm Proven by Autopsy

被引：5

作者：

Nakamura, Satoko ^{[1
]}

Ishibashi-Ueda, Hatsue ^{[2
]}

Suzuki, Chigure ^{[3
]}

Nakata, Hiroto ^{[1
]}

Yoshihara, Fumiki ^{[1
]}

Nakahama, Hajime ^{[1
]}

Kawano, Yuhei ^{[1
]}

机构：

[1] Natl Cardiovasc Ctr, Dept Med, Div Nephrol & Hypertens, Osaka 5658565, Japan

[2] Natl Cardiovasc Ctr, Dept Pathol, Osaka 5658565, Japan

[3] Osaka Grad Sch Med, Dept Nephrol, Osaka, Japan

来源：

KIDNEY & BLOOD PRESSURE RESEARCH | 2009年 / 32卷 / 01期

关键词：

Abdominal aortic aneurysm; Cardiovascular disease; Chronic kidney disease; Renal histological damage; Renal artery stenosis; CHRONIC KIDNEY-DISEASE; FOLLOW-UP; POPULATION; PREVALENCE; PREDICTORS; OUTCOMES;

D O I：

10.1159/000197865

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Background: Chronic kidney disease is a major risk factor for patients with cardiovascular diseases (CVD). The aim of this study is to evaluate the relationship between clinical characteristics and renal histology in patients with abdominal aortic aneurysm (AAA). Methods: We studied 79 cases with AAA autopsied at the National Cardiovascular Center. They were classified into two groups: 14 subjects with renal artery stenosis (RAS) (group A) and 65 subjects without RAS (group B). Proteinuria, elevated serum creatinine and decreased estimated glomerular filtration rate had been recorded. We evaluated renal parenchymal damage using a semiquantitative histological score (score 0-3; normal to severe) for glomerulosclerosis, interstitial fibrosis, tubular atrophy, and arteriolar hyalinosis (maximal score = 12). Results: Total histological score was 8.2 +/- 2.4 and significantly higher in the stenosed kidneys of group A than in the non-stenosed kidneys of group B (8.9 +/- 2.6 vs. 8.0 +/- 2.3). The histological score had a significant association with RAS, smoking, kidney function, proteinuria, kidney weight and the presence of other CVD. Conclusion: We demonstrated that renal parenchymal damage and deteriorated kidney function are closely associated in the patients with AAA. Treatment of these patients in view of protection of the kidney is thus relevant. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：11 / 16

页数：6