Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts

被引：9

作者：

Degola, Francesca ^{[1
]}

Marzouk, Belsem ^{[2
]}

Gori, Antonella ^{[3
]}

Brunetti, Cecilia ^{[3
,4
]}

Dramis, Lucia ^{[1
]}

Gelati, Stefania ^{[5
]}

Buschini, Annamaria ^{[1
,6
]}

Restivo, Francesco M. ^{[1
]}

机构：

[1] Univ Parma, Dept Chem Life Sci & Environm Sustainabil, Parco Area Sci 11-A, I-43124 Parma, Italy

[2] Univ Monastir, Fac Pharm Monastir, Lab Chem Galen & Pharmacol Dev Drugs, Monastir 5000, Tunisia

[3] Natl Res Council Italy CNR, Tree & Timber Inst IVALSA, Via Madonna Piano 10, I-50019 Florence, Italy

[4] Univ Florence, Dept Agr Environm Food & Forestry DAGRI, Piazzale Cascine 18, I-50144 Florence, Italy

[5] Expt Stn Food Preserving Ind SSICA, Dept Packaging, Viale Tanara 31-A, I-43121 Parma, Italy

[6] Ctr Mol & Translat Oncol, Parco Area Sci, I-43124 Parma, Italy

来源：

TOXINS | 2019年 / 11卷 / 05期

关键词：

antimycotoxigenic activity; Citrullus colocynthis; Aspergillus flavus; model system; HPLC-MS; MS; AFLATOXIN BIOSYNTHESIS; OXIDATIVE STRESS; REACTIVE OXYGEN; ANTIOXIDANT; GROWTH; GLYCOSIDES; FRUIT; CUCURBITACINS; ANTIBACTERIAL; PARASITICUS;

D O I：

10.3390/toxins11050286

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Citrullus colocynthis L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of C. colocynthis are used in folk Berber medicine for the treatment of numerous diseasessuch as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some C. colocynthis stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus Aspergillus flavus, testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities.

引用

页数：15

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