Acute presentation of craniopharyngioma in children and adults in a Danish national cohort

被引:13
作者
Nielsen, E. H. [1 ]
Jorgensen, J. O. [2 ]
Bjerre, P. [3 ]
Andersen, M. [4 ]
Andersen, C. [5 ]
Feldt-Rasmussen, U. [6 ]
Poulsgaard, L. [7 ]
Kristensen, L. O. [8 ]
Astrup, J. [9 ]
Jorgensen, J. [10 ]
Laurberg, P. [1 ]
机构
[1] Aarhus Univ Hosp, Aalborg Hosp, Dept Endocrinol, DK-9000 Aalborg, Denmark
[2] Aarhus Univ Hosp, Aarhus Sygehus, Med Dept M Endocrinol & Diabet, DK-8000 Aarhus, Denmark
[3] Aarhus Univ Hosp, Aarhus Sygehus, Dept Neurosurg, DK-8000 Aarhus, Denmark
[4] Odense Univ Hosp, Dept Endocrinol, Copenhagen, Denmark
[5] Odense Univ Hosp, Dept Neurosurg, Copenhagen, Denmark
[6] Copenhagen Univ Hosp, Rigshosp, Dept Endocrinol, Copenhagen, Denmark
[7] Copenhagen Univ Hosp, Rigshosp, Dept Neurosurg, Copenhagen, Denmark
[8] Univ Copenhagen, Herlev Hosp, Dept Endocrinol, Copenhagen, Denmark
[9] Univ Copenhagen, Glostrup Hosp, Dept Neurosurg, Copenhagen, Denmark
[10] Aarhus Univ Hosp, Aalborg Hosp, Dept Neurosurg, DK-9000 Aalborg, Denmark
关键词
Craniopharyngioma; Symptoms; Presentation; Children; Adults; Hydrocephalus; Pituitary tumour haemorrhage; GROWTH-HORMONE DEFICIENCY; QUALITY-OF-LIFE; GH DEFICIENCY; SURGICAL-MANAGEMENT; PITUITARY APOPLEXY; PEDIATRIC CRANIOPHARYNGIOMAS; CYSTIC CRANIOPHARYNGIOMAS; POSTERIOR-FOSSA; DIAGNOSIS; HYDROCEPHALUS;
D O I
10.1007/s11102-012-0451-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We aimed to study the occurrence of acute-onset symptoms at initial presentation in a national Danish cohort of patients with childhood- or adult-onset craniopharyngioma, and to investigate potential risk factors for acute presentation. Medical records of 189 consecutive patients (39 children, 150 adults) presenting with craniopharyngioma during the period 1985-2004 were reviewed, and data regarding initial symptoms, neuroimaging results, vision and pituitary function were systematically collected. Acute symptoms preceding hospital admission were noted. Subgroup analyses were based on age, gender and calendar year period. Potential risk factors for acute presentation were analysed through uni- and multivariate analyses. Acute symptoms were reported in 24 (13 %) patients. Acute visual symptoms, headache, nausea or vomiting were most frequently reported, and acute symptoms were more frequent among children (28 %) than among adults (9 %) (P < 0.01). There were no differences according to sex or calendar year period. Hydrocephalus was present in half of childhood cases and one-fifth of adult patients (P < 0.001). Intra-tumour haemorrhage was seen in two cases. Acute symptoms were more frequent among patients with tumours occupying the third ventricle (P < 0.01), radiologic signs of calcification (P < 0.05) or hydrocephalus (P < 0.01). In multivariate analysis, however, only childhood onset (P < 0.05) and calcification (P < 0.05) were independent risk factors for acute presentation. Craniopharyngioma presented with acute symptoms in 13 % of patients. Childhood onset and radiologic signs of calcification were independent risk factors for acute presentation. Intra-tumour haemorrhage was rare.
引用
收藏
页码:528 / 535
页数:8
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