Tumor-derived lactate and myeloid-derived suppressor cells Linking metabolism to cancer immunology

被引：109

作者：

Husain, Zaheed ^{[1
,2
]}

Seth, Pankaj ^{[1
,2
]}

Sukhatme, Vikas P. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Hosp, Div Interdisciplinary Med & Biotechnol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Hosp, Boston, MA USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期

关键词：

glycolysis; ketogenic diet; lactate; MDSCs; NK cells; EXPRESSION;

D O I：

10.4161/onci.26383

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.

引用

页数：3

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