Histone deacetylase inhibitor FK228 is a potent inducer of human fetal haemoglobin

被引：19
|
作者：
Cao, Hua [1 ]
Stamatoyannopoulos, George [1 ]
机构：
[1] Univ Washington, Div Med Genet, Seattle, WA 98195 USA
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 2006年 / 81卷 / 12期
关键词：
fetal hemoglobin; sickle cell disease; thalassemia; histone deacetylase inhibitors;
D O I：
10.1002/ajh.20676
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the induction of the human fetal globin gene using five potent histone deacetylase (HDAC) inhibitors: FK-228, HC-Toxin, Trichostatin, MS-275, and Apicidin, using in vitro assays and cultures of primary human erythroblasts. The results showed that FK228 is the most potent inducer of fetal hemoglobin and exhibits its effects in picomolar concentrations. FK228 should be considered as a potential therapeutic for induction of fetal hemoglobin in patients with beta chain hemoglobinopathies.
引用
收藏
页码：981 / 983
页数：3
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