Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32)

被引：10

作者：

Rashid, Rumana

Johnson, Roderick J.

Morris, Stephen

Dickinson, Helen

Czyz, Jarek

O'Connor, Sheila J. M.

Owen, Roger G.

机构：

[1] Leeds Teaching Hosp NHS Trust, HMDS Lab, Leeds LS1 3EX, W Yorkshire, England

[2] Gen Infirm Leeds, Leeds Teaching Hosp NHS Trust, Dept Hematol, Leeds, W Yorkshire, England

[3] Leeds Teaching Hosp NHS Trust, Reg Cytogenet Unit, Leeds, W Yorkshire, England

[4] Huddersfield Royal Infirm, Dept Hematol, Huddersfield HD3 3EA, W Yorkshire, England

来源：

CANCER GENETICS AND CYTOGENETICS | 2006年 / 171卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2006.07.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/ cyclin D1 dual-color, dual-fusion probe set and cyclin D1 immunohistochemical analysis. Abnormality of 3q was also evident. Interphase FISH analysis with a dual-color, break-apart probe set confirmed rearrangement of BCL6. To our knowledge, this is the first report of these abnormalities in IVL. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：101 / 104

页数：4

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