Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters

被引：84

作者：

Du, Jian ^{[1
]}

Sun, Lian-Na ^{[1
]}

Xing, Wei-Wei ^{[1
,2
]}

Huang, Bao-Kang ^{[1
]}

Jia, Min ^{[1
]}

Wu, Jin-Zhong ^{[3
]}

Zhang, Hong ^{[1
]}

Qin, Lu-Ping ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Pharmacognosy, Shenyang 110016, Peoples R China

[3] Fujian Coll Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 6-7期

关键词：

Polydatin; Polygonum cuspidatum; Lipid lowering; Hyperlipidaemias; Hamster; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; PARAOXONASE; PURIFICATION; RESVERATROL; EXTRACT; PROFILE; LIVER;

D O I：

10.1016/j.phymed.2008.10.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hyperlipidaemias are common in obese people, and they increase the risk of cardiovascular diseases such as coronary heart disease (CHD) and atherosclerosis (AS). Previous studies have shown that several drugs can depress serum cholesterol. However, they could cause serious side effects in various clinical settings. The objective of the present study was to evaluate the lipid-lowering effects of polydatin in high-fat/cholesterol (HFC)-fed hamsters. The levels of lipids in hamsters were measured enzymatically before and after the administration of polydatin. Significant differences between HFC and HFC + polydatin were detected for those concentrations. Decreased levels of serum TC, TG and LDL-C and the concentrations of hepatic TG were found. Experimental results also showed that polydatin elevated LDL-C/HDL-C and TC/HDL-C ratios. In concert with other effects, serum cholesterol-lowering effect in hamsters may contribute to the regulation properties attributed to polydatin. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：652 / 658

页数：7

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