The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration

被引：27

作者：

Dufourcq, Pascale

Vriz, Sophie

机构：

[1] Univ Paris 07, UFR Biol, F-75005 Paris, France

[2] Ecole Normale Super, INSERM, U368, F-75005 Paris, France

来源：

DEVELOPMENT GENES AND EVOLUTION | 2006年 / 216卷 / 10期

关键词：

regeneration; progenitor cells; chemokine; Sdf1; Cxcr4;

D O I：

10.1007/s00427-006-0066-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.

引用

收藏

页码：635 / 639

页数：5

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