Is neutralization of IFN-γ sufficient to control inflammation in HLH?

被引：8
作者：
Ehl, Stephan [1 ,2 ]
Greenwood, Tatiana von Bahr [3 ,4 ]
Bergsten, Elisabet [3 ]
Fischer, Alain [5 ,6 ,7 ]
Henter, Jan-Inge [3 ,4 ]
Hines, Melissa [8 ]
Lehmberg, Kai [9 ]
Janka, Gritta [10 ]
Moshous, Despina [6 ,11 ,12 ]
Nichols, Kim E. [13 ]
机构：
[1] Univ Freiburg, Ctr Chron Immunodeficiency, Inst Immunodeficiency, Med Ctr,Fac Med, Freiburg, Germany
[2] Univ Freiburg, Ctr Pediat, Med Ctr, Fac Med, Freiburg, Germany
[3] Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden
[4] Karolinska Univ Hosp, Pediat Oncol, Theme Childrens Hlth, Stockholm, Sweden
[5] Imagine Inst, Paris, France
[6] Hop Necker Enfants Malad, AP HP, Paediat Immunol Haematol & Rheumatol Unit, Paris, France
[7] Coll France, Paris, France
[8] St Jude Childrens Res Hosp, Div Crit Care, Dept Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA
[9] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Hematol & Oncol, Div Pediat Stem Cell Transplantat & Immunol, Hamburg, Germany
[10] Univ Med Ctr Hamburg Eppendorf, Clin Pediat Hematol & Oncol, Hamburg, Germany
[11] Imagine Inst, Genome Dynam Immune Syst, Paris, France
[12] Paris Descartes Univ, Sorbonne Paris Cite, Paris, France
[13] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA
来源：
PEDIATRIC BLOOD & CANCER | 2021年 / 68卷 / 03期
关键词：
CD8(+) T-CELLS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; INTERFERON-GAMMA; CYTOKINE PATTERN; CHILDREN; EMAPALUMAB;
D O I：
10.1002/pbc.28886
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：4
相关论文
共 22 条
  • [1] Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study
    Bergsten, Elisabet
    Horne, AnnaCarin
    Myrberg, Ida Hed
    Arico, Maurizio
    Astigarraga, Itziar
    Ishii, Eiichi
    Janka, Gritta
    Ladisch, Stephan
    Lehmberg, Kai
    McClain, Kenneth L.
    Minkov, Milen
    Nanduri, Vasanta
    Rosso, Diego A.
    Sieni, Elena
    Winiarski, Jacek
    Henter, Jan-Inge
    [J]. BLOOD ADVANCES, 2020, 4 (15) : 3754 - 3766
  • [2] Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
    Bergsten, Elisabet
    Horne, AnnaCarin
    Arico, Maurizio
    Astigarraga, Itziar
    Egeler, R. Maarten
    Filipovich, Alexandra H.
    Ishii, Eiichi
    Janka, Gritta
    Ladisch, Stephan
    Lehmberg, Kai
    McClain, Kenneth L.
    Minkov, Milen
    Montgomery, Scott
    Nanduri, Vasanta
    Rosso, Diego
    Henter, Jan-Inge
    [J]. BLOOD, 2017, 130 (25) : 2728 - 2738
  • [3] Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus
    Binder, D
    van den Broek, MF
    Kägi, D
    Bluethmann, H
    Fehr, J
    Hengartner, H
    Zinkernagel, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (11) : 1903 - 1920
  • [4] Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis
    Burn, Thomas N.
    Weaver, Lehn
    Rood, Julia E.
    Chu, Niansheng
    Bodansky, Aaron
    Kreiger, Portia A.
    Behrens, Edward M.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2020, 72 (02) : 335 - 347
  • [5] Comparison of Th1/Th2 cytokine profiles between primary and secondary haemophagocytic lymphohistiocytosis
    Chen, Yuanyuan
    Wang, Zhujun
    Luo, Zebin
    Zhao, Ning
    Yang, Shilong
    Tang, Yongmin
    [J]. ITALIAN JOURNAL OF PEDIATRICS, 2016, 42
  • [6] Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis
    Gather, Ruth
    Aichele, Peter
    Goos, Nadja
    Rohr, Jan
    Pircher, Hanspeter
    Koegl, Tamara
    Zeiser, Robert
    Hengel, Hartmut
    Schmitt-Graeff, Annette
    Weaver, Casey
    Ehl, Stephan
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2020, 50 (11) : 1770 - 1782
  • [7] Two decades of orphan product development
    Haffner, ME
    Whitley, J
    Moses, M
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (10) : 821 - 825
  • [8] Emapalumab in Primary Hemophagocytic Lymphohistiocytosis
    Henter, Jan-Inge
    Greenwood, Tatiana von Bahr
    Bergsten, Elisabet
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (06) : 596 - 598
  • [9] HYPERCYTOKINEMIA IN FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
    HENTER, JI
    ELINDER, G
    SODER, O
    HANSSON, M
    ANDERSSON, B
    ANDERSSON, U
    [J]. BLOOD, 1991, 78 (11) : 2918 - 2922
  • [10] IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis
    Humblet-Baron, Stephanie
    Franckaert, Dean
    Dooley, James
    Ailal, Fatima
    Bousfiha, Aziz
    Deswarte, Caroline
    Oleaga-Quintas, Carmen
    Casanova, Jean-Laurent
    Bustamante, Jacinta
    Liston, Adrian
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (06) : 2215 - +
123