Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications

被引：30

作者：

Cribbs, Adam ^{[1
,2
]}

Feldmann, Marc ^{[1
]}

Oppermann, Udo ^{[2
,3
]}

机构：

[1] Kennedy Inst Rheumatol, Oxford, England

[2] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, NIHR Oxford Biomed Res Unit, Botnar Res Ctr, Oxford OX3 7LD, England

[3] Univ Oxford, Struct Genom Consortium, Oxford OX3 7LD, England

来源：

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE | 2015年 / 7卷 / 05期

关键词：

DNA methylation; epigenetics; rheumatoid arthritis; CD4+ T-CELLS; METHYLTRANSFERASE GENE; MAMMALIAN DNA; MYELODYSPLASTIC SYNDROMES; EPIGENETIC MODIFICATIONS; CYTOSINE METHYLATION; PROMOTER METHYLATION; METHYLOME SIGNATURE; WIDE ASSOCIATION; CPG METHYLATION;

D O I：

10.1177/1759720X15598307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The term 'epigenetics' loosely describes DNA-templated processes leading to heritable changes in gene activity and expression, which are independent of the underlying DNA sequence. Epigenetic mechanisms comprise of post-translational modifications of chromatin, methylation of DNA, nucleosome positioning as well as expression of noncoding RNAs. Major advances in understanding the role of DNA methylation in regulating chromatin functions have been made over the past decade, and point to a role of this epigenetic mechanism in human disease. Rheumatoid arthritis (RA) is an autoimmune disorder where altered DNA methylation patterns have been identified in a number of different disease-relevant cell types. However, the contribution of DNA methylation changes to RA disease pathogenesis is at present poorly understood and in need of further investigation. Here we review the current knowledge regarding the role of DNA methylation in rheumatoid arthritis and indicate its potential therapeutic implications.

引用

页码：206 / 219

页数：14

共 124 条

[1]

AHO K, 1986, J RHEUMATOL, V13, P899

[2]

BEDNARIK DP, 1991, NEW BIOL, V3, P969

[3]

Bernard NJ, 2014, NAT REV RHEUMATOL, V10, DOI [10.1038/nrrheum.2014.180, 10.1038/nrrheum.2014.25, 10.1038/nrrheum.2014.88, 10.1038/nrrheum.2014.96, 10.1038/nrrheum.2014.141, 10.1038/nrrheum.2014.60, 10.1038/nrrheum.2014.166, 10.1038/nrrheum.2013.207, 10.1038/nrrheum.2014.170, 10.1038/nrrheum.2014.72, 10.1038/nrrheum.2013.187]

[4] CLONING AND SEQUENCING OF A CDNA-ENCODING DNA METHYLTRANSFERASE OF MOUSE CELLS - THE CARBOXYL-TERMINAL DOMAIN OF THE MAMMALIAN ENZYMES IS RELATED TO BACTERIAL RESTRICTION METHYLTRANSFERASES [J].