Highly Regio- and Enantioselective Synthesis of Polysubstituted 2H-Pyrroles via Pd-Catalyzed Intermolecular Asymmetric Allylic Dearomatization of Pyrroles

被引：78

作者：

Zhuo, Chun-Xiang ^{[1
]}

Zhou, Yong ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 18期

基金：

中国国家自然科学基金;

关键词：

FRIEDEL-CRAFTS ALKYLATION; ALKENE-PHOSPHINE LIGANDS; INDOLES; ALLYLATION; FUNCTIONALIZATION; CONSTRUCTION; BINAP; PYRROLOINDOLINES; HYDROGENATION; SUBSTITUTION;

D O I：

10.1021/ja5028138

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient synthesis of chiral polysubstituted 2H-pyrrole derivatives via a Pd-catalyzed intermolecular asymmetric allylic dearomatization reaction of pyrroles is presented. With the commercially available palladium precursor and chiral ligand, the polysubstituted 2H-pyrrole products containing a chiral quaternary carbon center were obtained with up to 97% ee and >95/5 regioselectivity.

引用

页码：6590 / 6593

页数：4

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