Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer

被引：77

作者：

Zhou, Liangfu ^{[1
]}

Zhao, Bin ^{[1
]}

Zhang, Lixiu ^{[1
]}

Wang, Shenghang ^{[1
]}

Dong, Dandan ^{[1
]}

Lv, Huanhuan ^{[1
,2
,3
]}

Shang, Peng ^{[2
,3
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Peoples R China

[2] Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China

[3] Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Inst Special Environm Biophys, Xian 710072, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

iron metabolism; cancer; iron chelators; targeted therapy; redox homeostasis; HEPATOCELLULAR-CARCINOMA CELLS; TRANSCRIPTION FACTOR NRF2; TRANSFERRIN RECEPTOR 2; HUMAN BREAST-CANCER; H-FERRITIN; IN-VIVO; REGULATORY PROTEIN-1; ANTITUMOR-ACTIVITY; PROSTATE-CANCER; TUMOR-GROWTH;

D O I：

10.3390/ijms19051545

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is an essential element for the growth and proliferation of cells. Cellular iron uptake, storage, utilization and export are tightly regulated to maintain iron homeostasis. However, cellular iron metabolism pathways are disturbed in most cancer cells. To maintain rapid growth and proliferation, cancer cells acquire large amounts of iron by altering expression of iron metabolism- related proteins. In this paper, normal cellular iron metabolism and the alterations of iron metabolic pathways in cancer cells were summarized. Therapeutic strategies based on targeting the altered iron metabolism were also discussed and disrupting redox homeostasis by intracellular high levels of iron provides new insight for cancer therapy. Altered iron metabolism constitutes a promising therapeutic target for cancer therapy.

引用

页数：21

共 190 条

[21] Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells? [J].

Bystrom, Laura M. ;

Guzman, Monica L. ;

Rivella, Stefano .

ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (12) :1917-1924

[22] Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory protein activity: A protective stratagem against oxidative injury [J].

Cairo, G ;

Castrusini, E ;

Minotti, G ;

BernelliZazzera, A .

FASEB JOURNAL, 1996, 10 (11) :1326-1335

[23] Transferrin receptor 2 is frequently expressed in human cancer cell lines [J].

Calzolari, Alessia ;

Oliviero, Isabella ;

Deaglio, Silvia ;

Mariam, Gualtiero ;

Biffoni, Mauro ;

Sposi, Nadia Maria ;

Malavasi, Fabio ;

Peschle, Cesare ;

Testa, Ugo .

BLOOD CELLS MOLECULES AND DISEASES, 2007, 39 (01) :82-91

[24] Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas [J].

Calzolari, Alessia ;

Larocca, Luigi Maria ;

Deaglio, Silvia ;

Finisguerra, Veronica ;

Boe, Alessandra ;

Raggi, Carla ;

Ricci-Vitani, Lucia ;

Pierconti, Francesco ;

Malavasi, Fabio ;

De Maria, Ruggero ;

Testa, Ugo ;

Pallini, Roberto .

TRANSLATIONAL ONCOLOGY, 2010, 3 (02) :123-134

[25] Regulation of transferrin receptor 2 in human cancer cell lines [J].

Calzolari, Alessia ;

Finisguerra, Veronica ;

Oliviero, Isabella ;

Deaglio, Silvia ;

Mariani, Gualtiero ;

Malavasi, Fabio ;

Testa, Ugo .

BLOOD CELLS MOLECULES AND DISEASES, 2009, 42 (01) :5-13

[26] Heme oxygenase-1: emerging target of cancer therapy [J].

Chau, Lee-Young .

JOURNAL OF BIOMEDICAL SCIENCE, 2015, 22

[27] Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin [J].

Chekhun, Vasyl F. ;

Lukyanova, Natalia Yu ;

Burlaka, Anatoliy P. ;

Bezdenezhnykh, Natalia A. ;

Shpyleva, Svitlana I. ;

Tryndyak, Volodymyr P. ;

Beland, Frederick A. ;

Pogribny, Igor P. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (05) :1481-1486

[28] Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation [J].

Chen, Caiyong ;

Garcia-Santos, Daniel ;

Ishikawa, Yuichi ;

Seguin, Alexandra ;

Li, Liangtao ;

Fegan, Katherine H. ;

Hildick-Smith, Gordon J. ;

Shah, Dhvanit I. ;

Cooney, Jeffrey D. ;

Chen, Wen ;

King, Matthew J. ;

Yien, Yvette Y. ;

Schultz, Iman J. ;

Anderson, Heidi ;

Dalton, Arthur J. ;

Freedman, Matthew L. ;

Kingsley, Paul D. ;

Palis, James ;

Hattangadi, Shilpa M. ;

Lodish, Harvey F. ;

Ward, Diane M. ;

Kaplan, Jerry ;

Maeda, Takahiro ;

Ponka, Prem ;

Paw, Barry H. .

CELL METABOLISM, 2013, 17 (03) :343-352

[29] Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues [J].

Chen, Q ;

Espey, MG ;

Krishna, MC ;

Mitchell, JB ;

Corpe, CP ;

Buettner, GR ;

Shacter, E ;

Levine, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13604-13609

[30] TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis [J].

Chen, TT ;

Li, L ;

Chung, DH ;

Allen, CDC ;

Torti, SV ;

Torti, FM ;

Cyster, JG ;

Chen, CY ;

Brodsky, FM ;

Niemi, EC ;

Nakamura, MC ;

Seaman, WE ;

Daws, MR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (07) :955-965

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