Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: Secondary analysis of a randomized, double-blind, placebo-controlled trial

被引:74
作者
van de Rest, Ondine [1 ]
van der Zwaluw, Nikita L. [1 ]
Tieland, Michael [1 ,2 ]
Adam, Jos J. [3 ]
Hiddink, Gert Jan [4 ,5 ]
van Loon, Luc J. C. [2 ,6 ]
de Groot, Lisette C. P. G. M. [1 ,2 ]
机构
[1] Wageningen Univ, Div Human Nutr, NL-6700 EV Wageningen, Netherlands
[2] Top Inst Food & Nutr, NL-6700 AN Wageningen, Netherlands
[3] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci MHeNS, Dept Human Movement Sci, NL-6200 MD Maastricht, Netherlands
[4] Wageningen Univ, Ctr Integrat Dev CTP CID, NL-6700 EW Wageningen, Netherlands
[5] Dutch Dairy Assoc NZO, NL-2700 AD Zoetermeer, Netherlands
[6] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Human Movement Sci, NL-6200 MD Maastricht, Netherlands
关键词
Frailty; Aging; Cognitive functioning; Exercise training; Protein supplementation; OLDER-ADULTS; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; DIETARY-PROTEIN; PERFORMANCE; MEMORY; STRENGTH; IMPAIRMENT; BENEFITS;
D O I
10.1016/j.mad.2013.12.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Physical activity has been proposed as one of the most effective strategies to prevent cognitive decline. Protein supplementation may exert an additive effect. The effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly people was assessed in a secondary analysis. Two 24-week, double-blind, randomized, placebo-controlled intervention studies were carried out in parallel. Subjects performed a resistance-type exercise program of two sessions per week (n = 62) or no exercise program (n = 65). In both studies, subjects were randomly allocated to either a protein (2 Chi 15 g daily) or a placebo drink. Cognitive functioning was assessed with a neuropsychological test battery focusing on the cognitive domains episodic memory, attention and working memory, information processing speed, and executive functioning. In frail and pre-frail elderly, resistance-type exercise training in combination with protein supplementation improved information processing speed (changes in domain score 0.08 +/- 0.51 versus 0.23 +/- 0.19 in the non-exercise group, p = 0.04). Exercise training without protein supplementation was beneficial for attention and working memory (changes in domain scores 035 +/- 0.70 versus 0.12 +/- 0.69 in the non-exercise group, p = 0.02). There were no significant differences among the intervention groups on the other cognitive tests or domain scores. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:85 / 93
页数:9
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