Platelet activation in chronic urticaria and its correlation with disease severity

被引:34
作者
Chandrashekar, Laxmisha [1 ]
Rajappa, Medha [2 ]
Sundar, Indhumathi [2 ]
Munisamy, Malathi [1 ]
Ananthanarayanan, P. H. [2 ]
Thappa, Devinder Mohan [1 ]
Toi, Pampa Ch [3 ]
机构
[1] Jawaharlal Inst Post Grad Med Educ & Res JIPMER, Dept Biochem, Dhanvantari Nagar 605006, Puducherry, India
[2] Jawaharlal Inst Post Grad Med Educ & Res, Dept Biochem, Dhanvantari Nagar 605006, Puducherry, India
[3] Jawaharlal Inst Post Grad Med Educ & Res, Dept Pathol, Dhanvantari Nagar 605006, Puducherry, India
关键词
Chronic urticaria; platelet aggregation; platelet indices; soluble P-selectin; P-SELECTIN; DISTRIBUTION WIDTH; PLASMA-LEVELS; VOLUME; PLATELET-FACTOR-4; RELEASE; PROTEIN; INDEXES;
D O I
10.3109/09537104.2013.786822
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Chronic urticaria (CU) is characterized by the occurrence of wheals lasting for more than 6 weeks. The role of platelet activation in the pathophysiology of this condition has not been clearly studied. We undertook a cross-sectional study among 45 patients with CU and 45 age-and gender-matched healthy controls. The severity of the disease was assessed using the urticaria severity score. The autologous plasma skin test (APST) was done in all cases of CU. The platelet count and indices were estimated by an automated haematological laser optical analyzer. Platelet aggregation and soluble P-selectin levels were estimated in all study participants. It was observed that there was a significantly higher mean platelet volume (MPV) and platelet distribution width (PDW) in patients with CU when compared to controls. Platelet aggregation and soluble P-selectin levels were significantly higher in patients with CU, as compared to controls. Urticaria severity score correlated positively with platelet aggregability and soluble P-selectin levels. APST-positive patients had significantly higher platelet aggregation and higher soluble P-selectin levels, when compared to the APST-negative patients, indicating more platelet activation in the autoimmune group. There is significant platelet activation in patients with CU, especially in those with autoreactivity.
引用
收藏
页码:162 / 165
页数:4
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