A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain

被引:51
作者
Baranidharan, Ganesan [1 ]
Das, Sangeeta [2 ]
Bhaskar, Arun [3 ]
机构
[1] Leeds Teaching Hosp NHS Trust, Leeds Pain & Neuromodulat Ctr, Seacroft Hosp, Leeds LS14 6UH, W Yorkshire, England
[2] Leeds Teaching Hosp NHS Trust, Leeds Pain & Neuromodulat Ctr, Leeds LS14 6UH, W Yorkshire, England
[3] Christie NHS Fdn Trust, Manchester, Lancs, England
关键词
Capsaicin; high concentration patch; neuropathic pain; post herpetic neauralgia; HIV; efficacy; POSTHERPETIC NEURALGIA; DOUBLE-BLIND; NGX-4010;
D O I
10.1177/1756285613496862
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the European Union, the high-concentration capsaicin patch is licensed for the management of neuropathic pain conditions in nondiabetic patients, including postherpetic neuralgia (PHN) and HIV-associated distal sensory polyneuropathy (HIV-DSP). However, in the USA, the Food and Drug Administration approved its use only in PHN patients. Capsaicin is a transient receptor potential vanilloid-1 agonist, which increases the intracellular calcium ion concentration. This triggers calcium-dependent protease enzymes causing cytoskeletal breakdown and leads to the loss of cellular integrity and 'defunctionalization' of nociceptor fibres. Efficacy and therapeutic effect has been shown in several clinical studies of PHN and HIV-DSP. The high-concentration capsaicin patch and its practical application are different from low-concentration creams; one application can help for up to 3 months. The process of setting up of a service to use the capsaicin 8% patch is also discussed.
引用
收藏
页码:287 / 297
页数:11
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