Controlled formation of the anhydrous polymorph of ciprofloxacin crystals embedded within chitosan scaffolds: study of the kinetic release dependence on crystal size

被引：15

作者：

Aranaz, I. ^{[1
]}

Gutierrez, M. C. ^{[1
]}

Yuste, L. ^{[2
]}

Rojo, F. ^{[2
]}

Ferrer, M. L. ^{[1
]}

del Monte, F. ^{[1
]}

机构：

[1] Inst Ciencia Mat, Madrid 28049, Spain

[2] CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 11期

关键词：

NANOPARTICLES; HYDROCHLORIDE; POLYMERS; SYSTEMS; GROWTH; CARBON; DRUG; FORM;

D O I：

10.1039/b813156b

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This work describes a simple procedure for preparation of chitosan (CHI) scaffolds containing ciprofloxacin (CFX) anhydrous crystals. The capability of CHI scaffolds to control the CFX crystal size and to preserve the anhydrous crystal habit even after long term storage was useful for the development of drug delivery systems (e.g., CFX/CHI scaffolds) exhibiting a novel way to control the kinetic release, that is, by the solubility/hydration ratio of CFX anhydrous crystals depending on their crystal size rather than by typical mechanisms based on swelling, hydration and/or erosion of the polymer acting as carrier.

引用

收藏

页码：1576 / 1582

页数：7

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