Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

被引：0

作者：

Gordon-Nunez, Manuel Antonio ^{[1
]}

Godoy, Gustavo Pina ^{[2
]}

Soares, Rosilene Calazans ^{[3
]}

de Souza, Lelia Batista ^{[4
]}

Freitas, Roseana de Almeida ^{[4
]}

Guedes Queiroz, Lelia Maria ^{[4
]}

机构：

[1] Panama UFRN, IFARHU SENACYT Program, Natal, RN, Brazil

[2] UEPB, Campina Grande, PB, Brazil

[3] Univ Fed Sergipe, Dept Morphol, Sergipe, S, Brazil

[4] Univ Fed Rio Grande do Norte, Post Graduat Program Oral Pathol, Natal, RN, Brazil

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2008年 / 26卷 / 03期

关键词：

Pleomorphic adenoma; Salivary gland tumour; p53; PCNA; bcl-2;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 proteins. It was observed weak labeling for p53 in 12 cases (63.1%) and for PCNA in 8 (42.1%). With respect to the bcl-2 labeling index, no expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably does not effectively participate in the pathogenesis of this tumor.

引用

页码：567 / 572

页数：6

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