Biology of circulating mRNA - Still more questions than answers?

被引：20
作者：
Fleischhacker, Michael [1 ]
机构：
[1] Univ Med Berlin, Med Klin Onkol Hamatol Molekularbiol Labor, D-10117 Berlin, Germany
来源：
CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM IV | 2006年 / 1075卷
关键词：
extracellular RNA; review; plasma; free-circulating RNA; cancer;
D O I：
10.1196/annals.1368.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A few years after the first description of free-circulating DNA in plasma and serum, the detection of tumor-associated overexpressed mRNA in plasma was also reported. This observation has been confirmed and it seems to be clear that the presence of free-circulating RNA is a ubiquitous phenomenon. In this short review I will discuss some basic aspects of the release mechanisms for the RNA, its biological meaning, and clinical value.
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页码：40 / 49
页数：10
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