Phage Therapy: What Have We Learned?

被引：95

作者：

Gorski, Andrzej ^{[1
,2
,3
]}

Miedzybrodzki, Ryszard ^{[1
,2
,3
]}

Lobocka, Malgorzata ^{[4
,5
]}

Glowacka-Rutkowska, Aleksandra ^{[4
]}

Bednarek, Agnieszka ^{[4
]}

Borysowski, Jan ^{[3
]}

Jonczyk-Matysiak, Ewa ^{[1
]}

Lusiak-Szelachowska, Marzanna ^{[1
]}

Weber-Dabrowska, Beata ^{[1
,2
]}

Baginska, Natalia ^{[1
]}

Letkiewicz, Slawomir ^{[2
,6
]}

Dabrowska, Krystyna ^{[1
,7
]}

Scheres, Jacques ^{[8
,9
]}

机构：

[1] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, Bacteriophage Lab, Rudolfa Weigla St 12, PL-53114 Wroclaw, Poland

[2] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, Phage Therapy Unit, Rudolfa Weigla St 12, PL-53114 Wroclaw, Poland

[3] Med Univ Warsaw, Transplantat Inst, Dept Clin Immunol, Nowogrodzka St 59, PL-02006 Warsaw, Poland

[4] Polish Acad Sci, Inst Biochem & Biophys, Pawinskiego St 5 A, PL-02106 Warsaw, Poland

[5] Warsaw Univ Life Sci, Fac Agr & Biol, Autonomous Dept Microbial Biol, Nowoursynowska St 159, PL-02776 Warsaw, Poland

[6] Katowice Sch Econ, Med Sci Inst, Harcerzy Wrzesnia St 3, PL-40659 Katowice, Poland

[7] Reg Specialized Hosp, Res & Dev Ctr, Kamienskiego 73a, PL-51124 Wroclaw, Poland

[8] Natl Inst Publ Hlth NIZP, Chocimska St 24, PL-00971 Warsaw, Poland

[9] Univ Med Ctr Groningen, Dept Med Microbiol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

来源：

VIRUSES-BASEL | 2018年 / 10卷 / 06期

关键词：

phage therapy; experimental therapy; phage cocktails; anti-phage antibodies; prophage; immunomodulation; RESTRICTION-MODIFICATION SYSTEM; MARKERLESS GENE DELETION; ABORTIVE INFECTION SYSTEM; ENCODED VIRULENCE FACTORS; WALL TEICHOIC-ACID; BROAD-HOST-RANGE; STAPHYLOCOCCUS-AUREUS; LACTOCOCCUS-LACTIS; ESCHERICHIA-COLI; CORYNEBACTERIUM-GLUTAMICUM;

D O I：

10.3390/v10060288

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this article we explain how current events in the field of phage therapy may positively influence its future development. We discuss the shift in position of the authorities, academia, media, non-governmental organizations, regulatory agencies, patients, and doctors which could enable further advances in the research and application of the therapy. In addition, we discuss methods to obtain optimal phage preparations and suggest the potential of novel applications of phage therapy extending beyond its anti-bacterial action.

引用

页数：28

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