Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection

被引：8

作者：

Horsley, Valerie ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06522 USA

来源：

JOURNAL OF CELL BIOLOGY | 2009年 / 185卷 / 05期

关键词：

HISTONE H3; OSTEOBLAST DIFFERENTIATION; MAMMARY-GLAND; PROTEIN; COMPLEX; WDR5; INITIATION; GENES; K4;

D O I：

10.1083/jcb.200904125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R. C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rheaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185: 811-826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of beta-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.

引用

页码：761 / 763

页数：3

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