Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

被引：118

作者：

Brunetta, Enrico ^{[1
,2
]}

Folci, Marco ^{[1
,2
]}

Bottazzi, Barbara ^{[1
]}

De Santis, Maria ^{[1
]}

Gritti, Giuseppe ^{[3
]}

Protti, Alessandro ^{[1
,2
]}

Mapelli, Sarah N. ^{[1
]}

Bonovas, Stefanos ^{[1
,2
]}

Piovani, Daniele ^{[1
,2
]}

Leone, Roberto ^{[1
]}

My, Ilaria ^{[1
,2
]}

Zanon, Veronica ^{[1
]}

Spata, Gianmarco ^{[1
]}

Bacci, Monica ^{[1
]}

Supino, Domenico ^{[2
]}

Carnevale, Silvia ^{[2
]}

Sironi, Marina ^{[1
]}

Davoudian, Sadaf ^{[1
]}

Peano, Clelia ^{[1
,4
]}

Landi, Francesco ^{[3
]}

Di Marco, Fabiano ^{[5
,6
]}

Raimondi, Federico ^{[5
]}

Gianatti, Andrea ^{[7
]}

Angelini, Claudio ^{[1
]}

Rambaldi, Alessandro ^{[3
,8
]}

Garlanda, Cecilia ^{[1
,2
]}

Ciccarelli, Michele ^{[1
]}

Cecconi, Maurizio ^{[1
,2
]}

Mantovani, Alberto ^{[1
,2
,9
]}

机构：

[1] Humanitas Clin & Res Ctr IRCCS, Milan, Italy

[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[3] Azienda Osped Socio Sanit Terr Papa Giovanni XXII, Unit Hematol, Bergamo, Italy

[4] CNR, UoS Milan, Inst Genet & Biomed Res, Milan, Italy

[5] Azienda Osped Socio Sanit Terr Papa Giovanni XXII, Unit Pneumol, Bergamo, Italy

[6] Univ Milan, Dept Hlth Sci, Milan, Italy

[7] Azienda Osped Socio Sanit Terr Papa Giovanni XXII, Unit Pathol, Bergamo, Italy

[8] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

[9] Queen Mary Univ London, William Harvey Res Inst, London, England

来源：

NATURE IMMUNOLOGY | 2021年 / 22卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

KAWASAKI-LIKE DISEASE; SHORT-TERM MORTALITY; INNATE IMMUNITY; INFECTION; INFLAMMATION; CORRELATE; SITES;

D O I：

10.1038/s41590-020-00832-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mantovani and colleagues report elevated circulating concentrations of the long pentraxin PTX3 in patients with severe COVID-19. Within this cohort, early detection of high PTX3 concentrations emerged as a strong predictor of decreased survival. Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation(1-3). The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)(4-7). RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.

引用

页码：19 / 24

页数：6

共 63 条

[61] A new coronavirus associated with human respiratory disease in China [J].

Wu, Fan ;

Zhao, Su ;

Yu, Bin ;

Chen, Yan-Mei ;

Wang, Wen ;

Song, Zhi-Gang ;

Hu, Yi ;

Tao, Zhao-Wu ;

Tian, Jun-Hua ;

Pei, Yuan-Yuan ;

Yuan, Ming-Li ;

Zhang, Yu-Ling ;

Dai, Fa-Hui ;

Liu, Yi ;

Wang, Qi-Min ;

Zheng, Jiao-Jiao ;

Xu, Lin ;

Holmes, Edward C. ;

Zhang, Yong-Zhen .

NATURE, 2020, 579 (7798) :265-+

[62] Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients [J].

Zhu, Linnan ;

Yang, Penghui ;

Zhao, Yingze ;

Zhuang, Zhenkun ;

Wang, Zhifeng ;

Son, Rui ;

Zhang, Jie ;

Liu, Chuanyu ;

Gao, Qianqian ;

Xu, Qumiao ;

Wei, Xiaoyu ;

Su, Hai-Xi ;

Ye, Beiwei ;

Wu, Yanan ;

Zhang, Ning ;

Lei, Guanglin ;

Yu, Lingxiang ;

Yan, Jin ;

Diao, Guanghao ;

Meng, Fanping ;

Bai, Changqing ;

Mao, Panyong ;

Yu, Yeya ;

Wang, Mingyue ;

Yuan, Yue ;

Deng, Qiuting ;

Li, Ziyi ;

Huang, Yunting ;

Hu, Guohai ;

Liu, Yang ;

Wang, Xiaoqian ;

Xu, Ziqian ;

Liu, Peipei ;

Bi, Yuhai ;

Shi, Yi ;

Zhang, Shaogeng ;

Chen, Zhihai ;

Wan, Jian ;

Xu, Xun ;

Wu, Guizhen ;

Wang, Fu-Sheng ;

Gao, George F. ;

Liu, Longqi ;

Liu, William J. .

IMMUNITY, 2020, 53 (03) :685-+

[63]

Zhu N, 2020, NEW ENGL J MED, V382, P727, DOI [10.1172/JCI89857, 10.1056/NEJMoa2001017]

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