Uncommon Chlorinated Xanthone and Other Antibacterial Compounds from the Lichen Cladonia incrassata

被引：18

作者：

Dieu, Amandine ^{[1
]}

Millot, Marion ^{[1
]}

Champavier, Yves ^{[2
]}

Mambu, Lengo ^{[1
]}

Chaleix, Vincent ^{[1
]}

Sol, Vincent ^{[1
]}

Gloaguen, Vincent ^{[1
]}

机构：

[1] Univ Limoges, Fac Pharm, Lab Chim Subst Nat, EA 1069, F-87025 Limoges, France

[2] Univ Limoges, Fac Pharm, Serv Commun Rech & Analyse Biomol Limoges, F-87025 Limoges, France

来源：

PLANTA MEDICA | 2014年 / 80卷 / 11期

关键词：

xanthone; Cladonia incrassata; Cladionaceae; antibacterial; Staphylococcus aureus; structure elucidation; ANTIMICROBIAL ACTIVITY; USNIC ACID; SECONDARY METABOLITES; (-)-USNIC ACID;

D O I：

10.1055/s-0034-1382827

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (-)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (-)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 mu g/mL).

引用

页码：931 / 935

页数：5

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