Genomic Assortative Mating in Marriages in the United States

被引：24

作者：

Guo, Guang ^{[1
,2
,3
]}

Wang, Lin ^{[4
]}

Liu, Hexuan ^{[1
,2
]}

Randall, Thomas ^{[5
]}

机构：

[1] Univ N Carolina, Dept Sociol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA

[3] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA

[4] Duke Univ, Ctr Child & Family Policy, Durham, NC USA

[5] NIEHS, Res Triangle Pk, NC 27709 USA

来源：

PLOS ONE | 2014年 / 9卷 / 11期

基金：

美国国家卫生研究院;

关键词：

BIOLOGICAL PATHWAYS; 5; DECADES; HEIGHT; LOCI; ASSOCIATION; DISORDERS; C6ORF217; VARIANTS; TRENDS; ADULT;

D O I：

10.1371/journal.pone.0112322

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Assortative mating in phenotype in human marriages has been widely observed. Using genome-wide genotype data from the Framingham Heart study (FHS; number of married couples = 989) and Health Retirement Survey (HRS; number of married couples = 3,474), this study investigates genomic assortative mating in human marriages. Two types of genomic marital correlations are calculated. The first is a correlation specific to a single married couple "averaged'' over all available autosomal single-nucleotide polymorphism (SNPs). In FHS, the average married-couple correlation is 0.0018 with p=3x10(-5); in HRS, it is 0.0017 with p=7.13x10(-13). The marital correlation among the positively assorting SNPs is 0.001 (p=.0043) in FHS and 0.015 (p=1.66x10(-24)) in HRS. The sizes of these estimates in FHS and HRS are consistent with what are suggested by the distribution of the allelic combination. The study also estimated SNP-specific correlation "averaged'' over all married couples. Suggestive evidence is reported. Future studies need to consider a more general form of genomic assortment, in which different allelic forms in homologous genes and non-homologous genes result in the same phenotype.

引用

页数：14

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