Composition of the outer membrane proteins of Escherichia coli strains in relation to serum susceptibility after exposure to subinhibitory concentrations of amikacin and ciprofloxacin

被引：12

作者：

Wojnicz, Dorota ^{[1
]}

Cisowska, Agnieszka ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Biol & Med Parasitol, PL-50367 Wroclaw, Poland

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2009年 / 33卷 / 06期

关键词：

Sub-MICs; Amikacin; Ciprofloxacin; OMPs; Bactericidal action of serum; HYDROPHOBICITY; ANTIBIOTICS; SENSITIVITY;

D O I：

10.1016/j.ijantimicag.2008.12.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effect of subinhibitory concentrations of amikacin and ciprofloxacin on the susceptibility of Escherichia coli strains to the bactericidal action of normal human serum, outer membrane protein (OMP) expression and cell morphology was investigated. Sub-minimal inhibitory concentrations (sub-MICs) of both antibiotics were found to alter the expression of some OMPs of serum-resistant E. coli rods, the morphology of their cells and made them sensitive to the bactericidal activity of normal human serum. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：579 / 582

页数：4

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