Improvement of juvenile dermatomyositis with calcinosis universalis after treatment with intravenous immunoglobulin

被引：6

作者：

Yang, Ming-Chun ^{[1
]}

Lee, Jyh-Hong ^{[1
]}

Yang, Yao-Hsu ^{[1
]}

Chiang, Bor-Luen ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2008年 / 11卷 / 01期

关键词：

calcinosis universalis; intravenous immunoglobulin; juvenile dermatomyositis;

D O I：

10.1111/j.1756-185X.2008.00336.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

juvenile dermatomyositis is a chronic multisystemic disease. It is believed to be of autoimmune aetiology and is characterized by the presence of vasculitis affecting striated muscle and skin. Calcinosis occurs in about 40% of cases. We report a case of a 10-year-old girl diagnosed with juvenile dermatomyositis who presented with difficulty in walking and inability to completely extend the four extremities due to calcinosis universalis. Calcinosis had progressed despite a 3-year administration of diltiazem, hydroxychloroquine, aluminium hydroxide, cyclosporin, and probenecid. The introduction of monthly intravenous immunoglobulin therapy for 15 months lessened disease activity, and markedly regressed calcinosis, and improved functional outcome.

引用

页码：77 / 80

页数：4

共 13 条

[1] Efficacy of early treatment of severe juvenile dermatomyositis with intravenous methylprednisolone and methotrexate [J].