Perspectives on RAGE Signaling and Its Role in Cardiovascular Disease

被引：23

作者：

Cohen, M. Michael, Jr. ^{[1
]}

机构：

[1] Dalhousie Univ, Dept Pediat, Fac Med, Halifax, NS B3N 1X7, Canada

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2013年 / 161卷 / 11期

关键词：

RAGE signaling; membrane-bound RAGE; secretory RAGE; cardiovascular disease; ischemia-reperfusion injury to the heart; AGEs; HMGB1; cancer; inflammation; Alzheimer disease; diabetes mellitus; renal disease; GLYCATION END-PRODUCTS; ENDPRODUCTS RAGE; RECEPTOR; INJURY; CONTRACTILITY; REGENERATION; PATHOGENESIS; ACTIVATION; EXPRESSION; PATHWAYS;

D O I：

10.1002/ajmg.a.36181

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RAGE stands for Receptor of Advanced Glycation Endproducts. The two main topics discussed are (1) the nature of RAGE signaling and (2) its role in cardiovascular disease. RAGE may occur in membrane-bound form or in secretory form. RAGE signaling involves multiple ligands: (1) several AGEs (2) amyloid pecursor protein (APP), (3) high mobility group box 1 (HMGB1), (4) S100A4, (5) S100A8/A9, and (6) S100A12, which are calcium-binding proteins, and (7) S100B, a glial-derived protein. RAGE ligands and various diseases involving RAGE signaling are summarized in tabular form. (c) 2013 Wiley Periodicals, Inc.

引用

页码：2750 / 2755

页数：6

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