SCHIZOPHRENIA A point of disruption

被引：7

作者：

Ross, Christopher A. ^{[1
,2
,3
]}

Margolis, Russell L. ^{[1
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol & Neurosci, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Program Cellular & Mol Med, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

来源：

NATURE | 2009年 / 458卷 / 7241期

关键词：

ADULT BRAIN; GENES; NEURONS; ILLNESS;

D O I：

10.1038/458976a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Much is still to be learned about the molecular basis of mental disorders. The identification of a signalling pathway that is affected in schizophrenia, and which thus provides potential therapeutic targets, is a welcome advance.

引用

页码：976 / 977

页数：2

共 15 条

[1] The Akt-GSK-3 signaling cascade in the actions of doparnine [J].

Beaulieu, Jean-Martin ;

Gainetdinov, Raul R. ;

Caron, Marc G. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (04) :166-172

[2] Disrupted in schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia [J].

Camargo, L. M. ;

Collura, V. ;

Rain, J-C ;

Mizuguchi, K. ;

Hermjakob, H. ;

Kerrien, S. ;

Bonnert, T. P. ;

Whiting, P. J. ;

Brandon, N. J. .

MOLECULAR PSYCHIATRY, 2007, 12 (01) :74-86

[3] The DISC locus in psychiatric illness [J].

Chubb, J. E. ;

Bradshaw, N. J. ;

Soares, D. C. ;

Porteous, D. J. ;

Millar, J. K. .

MOLECULAR PSYCHIATRY, 2008, 13 (01) :36-64

[4] Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain [J].

Duan, Xin ;

Chang, Jay H. ;

Ge, Shaoyu ;

Faulkner, Regina L. ;

Kim, Ju Young ;

Kitabatake, Yasuji ;

Liu, Xiao-bo ;

Yang, Chih-Hao ;

Jordan, J. Dedrick ;

Ma, Dengke K. ;

Liu, Cindy Y. ;

Ganesan, Sundar ;

Cheng, Hwai-Jong ;

Ming, Guo-li ;

Lu, Bai ;

Song, Hongjun .

CELL, 2007, 130 (06) :1146-1158

[5] Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain [J].

Faulkner, Regina L. ;

Jang, Mi-Hyeon ;

Liu, Xiao-Bo ;

Duan, Xin ;

Sailor, Kurt A. ;

Kim, Ju Young ;

Ge, Shaoyu ;

Jones, Edward G. ;

Ming, Guo-li ;

Song, Hongjun ;

Cheng, Hwai-Jong .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (37) :14157-14162

[6] Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence [J].

Harrison, PJ ;

Weinberger, DR .

MOLECULAR PSYCHIATRY, 2005, 10 (01) :40-68

[7] Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions [J].

Jope, Richard S. ;

Roh, Myoung-Suin .

CURRENT DRUG TARGETS, 2006, 7 (11) :1421-1434

[8] A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development [J].

Kamiya, A ;

Kubo, K ;

Tomoda, T ;

Takaki, M ;

Youn, R ;

Ozeki, Y ;

Sawamura, N ;

Park, U ;

Kudo, C ;

Okawa, M ;

Ross, CA ;

Hatten, ME ;

Nakajima, K ;

Sawa, A .

NATURE CELL BIOLOGY, 2005, 7 (12) :1167-1178

[9] Cortical inhibitory neurons and schizophrenia [J].

Lewis, DA ;

Hashimoto, T ;

Volk, DW .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (04) :312-324

[10] Wnt signalling regulates adult hippocampal neurogenesis [J].

Lie, DC ;

Colamarino, SA ;

Song, HJ ;

Désiré, L ;

Mira, H ;

Consiglio, A ;

Lein, ES ;

Jessberger, S ;

Lansford, H ;

Dearie, AR ;

Gage, FH .

NATURE, 2005, 437 (7063) :1370-1375

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