Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

被引：36
作者：
Florey, O. [1 ]
Kim, S. E. [2 ,3 ]
Overholtzer, M. [2 ,3 ]
机构：
[1] Babraham Inst, Signalling Programme, Cambridge CB22 3AT, England
[2] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA
[3] Weill Cornell Med Coll, BCMB Allied Program, New York, NY 10065 USA
来源：
CURRENT MOLECULAR MEDICINE | 2015年 / 15卷 / 09期
关键词：
Cell-in-cell; entosis; entotic cell death; cannibalism; phagocytosis; engulfment; autophagy; LAP; cell competition; AUTOPHAGY PROTEINS; HUMAN CANCERS; TUMOR-CELLS; MYOSIN-II; PHAGOCYTOSIS; COMPETITION; MACROAUTOPHAGY; ACTIVATION; MECHANISMS; ENGULFMENT;
D O I：
10.2174/1566524015666151026100042
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
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收藏
页码：861 / 866
页数：6
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