Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

被引：155
作者：
Siarey, RJ
Carlson, EJ
Epstein, CJ
Balbo, A
Rapoport, SI
Galdzicki, Z [1 ]
机构：
[1] NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA
[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA
来源：
NEUROPHARMACOLOGY | 1999年 / 38卷 / 12期
关键词：
Down syndrome; Ts65Dn; long-term potentiation; long-term depression; hippocampus; mental retardation;
D O I：
10.1016/S0028-3908(99)00083-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
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收藏
页码：1917 / 1920
页数：4
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