A microwave-assisted facile synthesis of novel coumarin derivatives containing cyanopyridine and furan as antimicrobial agents

被引：21

作者：

Desai, N. C. ^{[1
]}

Satodiya, H. M. ^{[1
]}

Rajpara, K. M. ^{[1
]}

Joshi, V. V. ^{[1
]}

Vaghani, H. V. ^{[1
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, UGC NONSAP & DST FIST Sponsored Dept, Dept Chem, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2017年 / 21卷

关键词：

Microwave-assisted synthesis; Coumarin; Cyanopyridine; Antimicrobial agents; SCHIFF-BASES; THIAZOLE DERIVATIVES; ANTIBACTERIAL; EFFICIENT;

D O I：

10.1016/j.jscs.2013.12.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, we have described the microwave-assisted method for the synthesis of novel 4-(substitutedphenyl)-2-(furan-2-ylmethyleneamino)-6-(2-oxo-2H-chromen-3-yl) nicotinonitriles (5a-m). Compound (I) 3-acetyl-2H-chromen-2-one was reacted with aromatic aldehydes, malononitrile and ammonium acetate in microwave conditions afforded compounds 3a-m, which on further microwave irradiation at 300 W for 8-10 min in the presence of trace amount of ZnCl2 furnished 5a-m. Structures of synthesized compounds have been confirmed by IR, H-1 NMR, C-13 NMR and mass spectra. Antimicrobial activity of the compounds was studied against several bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes) and fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) by using the serial broth dilution method. Five compounds 5d, 5f, 5j, 5k and 5l were found to possess high activity comparable to ampicillin at 50 mu g/ml against E. coli and P. aeruginosa. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.

引用

页码：S153 / S162

页数：10

共 21 条

[1] Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives [J].