RETRACTED: Simultaneous Adsorption of Anionic Surfactant and Non-Ionic Polymer Onto Griseofulvin Nanoparticles Prepared by Wet Bead Milling (Retracted Article)

Griseofulvin nanoparticles could be prepared by wet bead milling drug in presence of either of the anionic surfactants, sodium dodecyl sulphate or aerosol-OT but not using the non-ionic polymer, hydroxypropylmethylcellulose (HPMC). Due to problems likely to be encountered when using nanoparticles stabilised by anionic surfactant, the possibility of exploiting the interaction that occurs between ionic and non-ionic stabilisers was investigated in an attempt to reduce the amount of anionic surfactant coating the nanoparticles. By including non-ionic polymer into the anionic surfactant-drug slurry before milling, the effect of varying HPMC molecular weight and surfactant/ polymer concentration on nanoparticle production was established. Furthermore the amount of anionic surfactant adsorbed on the griseofulvin nanoparticle surfaces was determined indirectly by measuring its depletion from solution using spectroscopy, while polymer adsorption was assessed via small angle neutron scattering (SANS). Inclusion of HPMC 8000 in the milling slurry resulted in its co-adsorption with anionic surfactant on the griseofulvin nanoparticle surfaces and a subsequent reduction of the amount of anionic surfactant required for stabilisation of the nanoparticles. The observed polymer-surfactant synergy is of emerging interest in pharmaceutical nanotechnology.